Papers
Eroglu, A., Russo, M.J., Bieganski, R., Fowler, A., Cheley, S., Bayley, H. and Toner, M. Intracellular trehalose improves the survival of cryopreserved mammalian cells. Nature Biotechnology 18, 163-167 (2000) pdf
Howorka, S., Movileanu, L., Lu, X., Magnon, M., Cheley, S., Braha, O. and Bayley, H. A protein pore with a single polymer chain tethered within the lumen. J. Am. Chem. Soc. 122, 2411-2416 (2000) pdf
Gu, L., Dalla Serra, M., Vincent, J.B., Vigh, G., Cheley, S., Braha, O. and Bayley, H. Reversal of charge selectivity in transmembrane protein pores by using non-covalent molecular adapters. Proc. Natl. Acad. Sci. USA 97, 3959-3964 (2000) pdf
Braha, O., Gu, L., Zhou, L., Lu, X., Cheley, S. and Bayley, H. Simultaneous stochastic sensing of divalent metal ions, Nature Biotechnology 18, 1005-1007 (2000) pdf
Conlan, S., Zhang, Y., Cheley, S. and Bayley, H. Biochemical and biophysical characterization of OmpG: a monomeric porin, Biochemistry 39, 11845-11854 (2000) pdf
Gu, L. and Bayley, H. Interaction of the non-covalent molecular adapter, b -cyclodextrin, with the staphylococcal a -hemolysin pore, Biophys. J. 79, 1967-1975 (2000) pdf
Movileanu, L., Howorka, S., Braha, O. and Bayley, H. Detecting protein analytes that modulate transmembrane movement of a polymer chain within a single protein pore, Nature Biotechnology 18, 1091-1095 (2000) pdf
Howorka, S., Sára, M., Wang, Y., Kuen, B., Sleytr, U.B., Lubitz, W. and Bayley, H. Surface accessible residues in the monomeric and assembled forms of a bacterial surface layer protein, J. Biol. Chem. 275, 37876-37886 (2000) pdf
Sanchez-Quesada, J., Ghadiri, M.R., Bayley, H. and Braha, O. Cyclic peptides as molecular adapters for a pore-forming protein, J. Am. Chem. Soc. 122, 11757-11766 (2000) pdf
Glazier , S.A. , Vanderah, D.J., Plant, A.L., Bayley, H., Valincius, G. and Kasianowicz, J.J. Reconstitution of the pore-forming toxin a -hemolysin in phospholipid/18-octadecyl-1-thiahexa(ethylene oxide) and phospholipid/n-octadecanethiol supported bilayer membranes, Langmuir 16, 10428-10435 (2000) pdf
Schuster, B., Pum, D., Sára, M., Braha, O., Bayley, H. and Sleytr, U.B. S-layer ultrafiltration membranes: a new support for stabilizing functionalized lipid membranes, Langmuir 17, 499-503 (2001) pdf
Gu, L.-Q., Cheley, S. and Bayley, H. Capture of a single molecule in a nanocavity, Science 291, 636-640 (2001) pdf
Movileanu, L., Cheley, S., Howorka, S., Braha, O. and Bayley, H. Location of a constriction in the lumen of a transmembrane pore by targeted covalent attachment of polymer molecules, J. General Physiology 117, 239-251 (2001) pdf
Howorka, S., Cheley, S. and Bayley, H. Sequence-specific detection of individual DNA strands using engineered nanopores, Nature Biotechnology 19, 636-639 (2001) pdf
Miles, G., Cheley, S., Braha, O. and Bayley, H. The staphylococcal leukocidin bi-component toxin forms large ionic channels, Biochemistry 40, 8514-8522 (2001) pdf
Zou, K., Miller, W.T., Givens, R.S. and Bayley, H. Caged thiophosphotyrosine peptides, Angew. Chem. Int. Ed. 40, 3049-3051 (2001) pdf
Movileanu, L. and Bayley, H. Partitioning of a polymer into a nanoscopic pore obeys a simple scaling law, Proc. Natl. Acad. Sci. USA 98 , 10137-10141 (2001) pdf
Howorka, S., Movileanu, L., Braha, O. and Bayley, H. Kinetics of duplex formation for individual DNA strands within a single protein nanopore, Proc. Natl. Acad. Sci. USA 98 , 12996-13001 (2001) pdf
Gu, L.-Q., Cheley, S. and Bayley, H. Prolonged residence time of a noncovalent molecular adapter, b -cyclodextrin, within the lumen of mutant a -hemolysin pores , J. General Physiology 118, 481-494 (2001) pdf
Chen,T., Acker, J.P., Eroglu, A., Cheley, S., Bayley, H., Fowler, A. and Toner, M. Beneficial effects of intracellular trehalose on the membrane integrity of dried mammalian cells, Cryobiology 43, 168-181 (2001) pdf
Miles, G., Movileanu, L. and Bayley, H. Subunit composition of a bicomponent toxin: staphylococcal leukocidin forms an octameric transmembrane pore, Protein Science 11, 894-902 (2002) pdf
Miles, G., Bayley, H. and Cheley, S. Properties of Bacillus cereus hemolysin II: a heptameric transmembrane pore , Protein Science 11, 1813-1824 (2002) pdf
Zou,K., Cheley, S., Givens, R.S. and Bayley, H. Catalytic subunit of protein kinase A caged at the activating phosphothreonine, J. Am. Chem. Soc. 104,8220-8229 (2002) pdf
Cheley, S., Gu, L.-Q. and Bayley, H. Stochastic sensing of nanomolar inositol 1,4,5-trisphosphate with an engineered pore . Chemistry & Biology 9, 829-838 (2002) pdf
Shin, S.-H., Luchian, T., Cheley, S., Braha, O. and Bayley, H. Kinetics of a reversible covalent-bond forming reaction observed at the single-molecule level . Angew. Chem. Int. Ed. 41, 3707-3709 (2002) pdf
Peterman, M.C., Ziebarth J.M., Braha, O., Bayley, H., Fishman, H.A. and Bloom, D.M. Ion channels and lipid bilayer membranes under high potentials using microfabricated apertures. Biomed. Microdevices 4, 231-236 (2002) pdf
Howorka, S. and Bayley, H. Probing distance and electrical potential within a protein pore with tethered DNA. Biophys. J. 83, 3202-3210 (2002) pdf
Acker, J.P., Lu, X.-m., Young, V., Cheley, H., Bayley, H., Fowler, A. and Toner, M. Measurement of trehalose loading of mammalian cells porated with a metal-actuated switchable pore. Biotechnol. Bioeng. 82, 525-532 (2003) pdf
Luchian, T., Shin, S.-H. and Bayley, H. Kinetics of a three-step reaction observed at the single-molecule level. Angew. Chem. Int. Ed. 42 , 1926-1929 (2003) pdf
Movileanu, L., Cheley, H. and Bayley, H. Partitioning of individual flexible polymers into a nanoscopic protein pore. Biophys. J. 85, 897-910 (2003) pdf
Conlan, S. and Bayley, H. Folding pathway of a monomeric porin, OmpG, in detergent solution.Biochemistry 42 , 9453-9465 (2003) pdf
Luchian, T., Shin, S.-H. and Bayley, H. Single-molecule covalent chemistry with spatially separated reactants. Angew. Chem. Int. Ed. 42, 3766-3771 (2003) pdf
Gu, L.-Q., Cheley, S. and Bayley, H. Electroosmotic enhancement of the binding of a neutral molecule to a transmembrane pore. Proc. Natl. Acad. Sci. USA 100, 15498-15503 (2003) pdf
Howorka, S., Nam , J., Bayley, H. and Kahne, D. Stochastic detection of monovalent and bivalent protein-ligand interactions. Angew. Chem. Int. Ed. 43, 842-846 (2004) pdf
Sánchez-Quesada, J., Saghatelian, A., Cheley, S., Bayley, H. and Ghadiri, M.R. Single molecule DNA rotaxanes of a transmembrane pore protein. Angew. Chem. Int. Ed. 43, 3063-3067 (2004) pdf
Xie,H., Braha, O., Gu, L.-Q., Cheley, S. and Bayley, H. Single-molecule observation of the catalytic subunit of cAMP-dependent protein kinase binding to an inhibitor peptide. Chemistry & Biology 12, 109-120 (2005) pdf
Ashkenasy, N., Sánchez-Quesada, J., Bayley, H. and Ghadiri, M.R. Recognizing a single base in an individual DNA strand: a step toward nanopore DNA sequencing. Angew. Chem. Int. Ed . 44, 1401-1404 (2005) pdf
Kang, X.-f., Gu, L.-Q., Cheley, S. and Bayley, H. Single protein pores containing molecular adapters at high temperatures. Angew. Chem. Int. Ed . 44, 1495-1499 (2005) pdf
Holden, M.A. and Bayley, H. Direct introduction of single protein channels and pores into lipid bilayers. J. Am. Chem. Soc. 127, 6502-6503 (2005) pdf
Jung, Y., Cheley, S., Braha, O. and Bayley, H. The internal cavity of the staphylococcal a -hemolysin pore accommodates ~175 exogenous amino acid residues , Biochemistry 44, 8919-8929 (2005). pdf
Movileanu, L., Schmittschmitt, J.P., Scholtz, J.M. and Bayley, H. Interactions of peptides with a protein pore . Biophys. J. 89 , 1030-1045 (2005).
Shin, S.H. and Bayley, H. Stepwise growth of a single polymer chain. J. Am. Chem. Soc. 127, 10462-10463 (2005). pdf
Guan, X., Gu, L.-Q., Cheley, S., Braha, O. and Bayley, H. Stochastic sensing of TNT with a genetically engineered pore . ChemBioChem 6, 1875-1881 (2005). pdf
Jayasinghe, L. and Bayley, H. The leukocidin pore: evidence for an octamer with four LukS subunits and four LukF subunits alternating around a central axis. Protein Science 14, 2550-2561 (2005). pdf
Jayasinghe, L., Miles, G. and Bayley, H. Role of the amino latch of staphylococcal a -hemolysin in pore formation: a co-operative interaction between the N terminus and position 217. J. Biol. Chem. 281, 2195-2204 (2006). pdf
Miles, G., Jayasinghe, L. and Bayley, H. Assembly of the bi-component leukocidin pore examined by truncation mutagenesis. J. Biol. Chem. 281, 2205-2214 (2006). pdf
Astier, Y., Braha, O. and Bayley, H. Toward single molecule DNA sequencing: direct identification of ribonucleoside and deoxyribonucleoside 5' -monophosphates by using an engineered protein nanopore equipped with a molecular adapter, J. Am. Chem. Soc. 128, 1705-1710 (2006). pdf
Holden, M., Jayasinghe, L., Daltrop, O. and Bayley, H. Rapid screening of membrane protein libraries- single-channel recording after direct transfer from expression colonies, submitted.
Reviews
Bayley, H., Braha, O., and Gu, L.-Q. Stochastic sensing with protein pores, Adv. Mater. 12, 139-142 (2000) pdf
Bayley, H., and Martin, C.R. Resistive-pulse sensing: from microbes to molecules, Chem. Rev. 100, 2575- 2594 (2000) pdf
Howorka, S., and Bayley, H. High-throughput scanning mutagenesis by recombination PCR, in Methods in molecular biology, vol. 182, chapter 16, In vitro mutagenesis protocols, J. Braman, ed., Humana Press, 141-149 (2001) pdf
Bayley, H. and Cremer, P.S. Stochastic sensors inspired by biology, Nature 413, 226-230 (2001) pdf
Bayley, H., Braha, O., Cheley, S. and Gu, L.-Q. Engineered nanopores, Chapter 7 in NanoBiotechnology, pp 93-112, C.M. Niemeyer and C.A. Mirkin, eds., Wiley-VCH Verlag (2004) pdf
Bayley, H. and Jayasinghe, L. Functional engineered channels and pores, Mol. Membrane Biol. 21, 209-220 (2004) pdf
Loudwig, S. and Bayley, H. Light-activated proteins: an overview, pp 253-304 in M. Goeldner and R. Givens, eds., Wiley-VCH Verlag (2005) pdf
Bayley, H., Jayasinghe, L. and Wallace, M. Prepore for a breakthrough, Nature Struct. Mol. Biol. 12, 385-386 (2005). pdf
Astier, Y., Bayley, H. and Howorka, S. Protein components for nanodevices, Curr. Op. Chem. Biol. 9, 576-584 (2005). pdf
Bayley, H. Ion channels get flashy, Nature Chem. Biol. 2, 11-13 (2006).
