Department of Chemistry

Department of Chemistry University of Oxford

Nature Comms paper highlights a new strategy for PPIs

Nature Comms paper highlights a new strategy  for PPIs

Nature Comms paper highlights a new strategy for targeting protein-protein interactions (PPIs) for the development of new small molecule therapeutics.
Results from a collaboration between the Rabbitts Group (MRC Weatherall Institute of Molecular Medicine, WIMM) and the Russell group (Depts Chemistry and Pharmacology) has recently been published in Nature Communications. The paper entitled ‘Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment’ describes a new approach using intracellular antibody fragments to block Protein-Protein Interactions (PPIs), use the fragments for target validation in disease models, and develop new small molecules against the PPI epitope. The work by the Rabbitts and Russells Groups used the approach to identify RAS-binding compounds with the aim of developing potential treatments for RAS-dependent cancers.
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