PIROXICAM:C
15H13N3O4SBY AMANDA PLIMMER, LINCOLN COLLEGE
Mr=331.345
Piroxicam is a non-steroidal anti-inflammatory agent from the oxicam group. It blocks prostaglandin synthesis through the inhibition of the enzyme cyclooxygenate.
USES
Primarily, it is used for the treatment of rheumatoid diseases. It reduces pain, joint swelling and morning stiffness and improves functionality of the joints during chronic polyarthiritis. Whether it is advantageous for affected joints in the long run is not clear. It is taken in the form of film coated tablets.
SIDE EFFECTS
At least 10% of subjects have adverse reactions including dyspepsia, nausea, vomiting and epigastric pain. It remains controversial if Piroxicam causes more dangerous gastrointestinal complications than other anti-inflammatory agents. The F.D.A. has not consented to ascribing Piroxicam an increased danger rating.
Frequent skin reactions are more likely than with other anti-inflammatory drugs. It also occasionally causes central nervous disorders (e.g. headaches, vertigo), renal problems, increased liver enzymes, hepatitis or hematologic disorders.
CAUTIONS
The longer a treatment with anti-inflammatory drugs last, the higher is the risk of dangerous gastrointestinal complications.
It should not be taken by those with an active peptic ulcer or hypersensitivity to aspirin or to other anti-inflammatory agents. There is a greater risk to pregnant women, nursing mothers, children, the elderly and those with renal failure or liver insufficiency.