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Research highlighted in Angewandte ChemieResearch highlighted in Angewandte Chemie

A recent paper by Andrew Jupp and Jose Goicoechea has been highlighted in Angewandte Chemie). The original article, which was published in the Journal of the American Chemical Society late last year, described the synthesis of a phosphorus-containing analogue of urea (phosphinecarboxamide). The Angewandte Highlight raises interesting questions regarding the influence of "heavy" p-block elements on the physical and chemical properties of relatives of well-established organic molecules. It concludes that the compound offers "great potential for the development of innovative applications or new synthetic pathways that may pave a way to further exciting molecules”.

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Hot Article in AnalystHot Article in Analyst

The paper "Nanoparticles in Sensing Applications: On What Timescale Do Analyte Species Adsorb on the Particle Surface?" by Enno Kätelhön and Richard G. Compton has been selected as a hot article.

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On the cover of Chemical Physics LettersOn the cover of Chemical Physics Letters

For the second time in March 2014 a paper from the Compton group is featured on the cover of Chemical Physics Letters! The most recent is a 'Frontiers Article' entitled 'Simultaneous electrochemical and 3D optical imaging of silver nanoparticles' by Christopher Batchelor-McAuley, Kristina Tschulik and Richard Compton together with collaborators from Paris, France.

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CrystEngComm cover and Hot ArticleCrystEngComm cover and Hot Article

A study by DPhil student Ines Collings has been highlighted on the cover of CrystEngComm. Ines's work develops a simple rule that allows the mechanical behaviour of framework materials to be predicted based only on their geometry and was selected by the journal editors as February's top 'Hot Article'

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HOT Article in Organic & Biomolecular ChemistryHOT Article in Organic & Biomolecular Chemistry

The research paper by Steve Davies et al. describing the asymmetric synthesis of C(5)-substituted transpentacins via a diasereoselective Ireland–Claisen protocol has been selected to be featured as a HOT article in Organic & Biomolecular Chemistry.

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Inorganic Chemistry Graduate Symposium and 2014 Malcolm Green LectureInorganic Chemistry Graduate Symposium and 2014 Malcolm Green Lecture

The Inorganic Chemistry Graduate Symposium took place on 25th - 26th March. This featured excellent research presentations by 33 final year graduate students across the full range of inorganic chemistry. The Symposium culminated in the 2014 Malcolm Green Lecture, presented by Professor Harry B Gray from the California Institute of Technology (pictured with Malcolm Green, Professor and Head of Inorganic Chemistry until 2003), and his lecture was entitled "Solar-Driven Water Splitting".

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On the Cover of Angewandte ChemieOn the Cover of Angewandte Chemie

In a communication A. D. Hamilton, S. Thompson, et al. reveal a strategy for mediating β-sheet interactions through the use of a tetrasubstituted diphenylacetylene to induce the formation of β-sheet structures in two directions. β-Sheets, key secondary structural elements of folded proteins, are commonly involved in therapeutically important protein–protein interactions and are a critical constituent of amyloid deposits in many neurodegenerative conditions. (illustration by Dr. Karl Harrison).

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COVER OF CHEMICAL PHYSICS LETTERSCOVER OF CHEMICAL PHYSICS LETTERS

The cover of the March 18th issue of CPL features an article entitled "Equality of diffusion-limited chronoamperometric currents to equal area spherical and cubic nanoparticles on a supporting electrode surface" authored by Enno Kaetelhoen, Eddy Barnes and Richard Compton together with collaborators from Julich, Germany. The image was created by Enno

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Chemistry at WOW HOWChemistry at WOW HOW

Wow! How? is an annual volunteer-run family science fair held at the Museum of Natural History and the Pitt Rivers Museum. Attracting thousands of visitors each year, the one-day event takes place during National Science & Engineering Week. It is also part of the annual Oxfordshire Science Festival.

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On the cover of Angewandte ChemieOn the cover of Angewandte Chemie

An article by Anna Rydzik and Jurgen Brem from Schofield group in collaboration with Tim Claridge was featured on the front cover of Angewandte Chemie. The work looks at monitoring conformational changes in the NDM-1 Metallo-β-lactamase by 19F NMR spectroscopy.

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Solving the energy crisis: from crystals to solar fuelsSolving the energy crisis: from crystals to solar fuels

Oxford chemists bring an interactive stand to Oxfordshire Science Festival 2014. In partnership with the Museum of History of Science 'Crystals Day', Imperial College, London, & the Solar Fuels Network.

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I’m a Scientist, Get me out of hereI’m a Scientist, Get me out of here

Mark Wallace is joining the ‘I’m a Scientist, Get me out of here’ competition this March. Hoping to inspire school students about science, Mark risks being ‘voted off’ or stands to win £500 towards science communication. ‘I’m a Scientist, Get me out of here’ is a free online X Factor-style competition where school students get to meet and interact with scientists, and students are the judges. Students challenge the scientists over intense, fast-paced online live chats. They then ask the scientists all the questions they want to, and vote for their favourite scientist to win the £500 prize. Tutorial Fellow and Lecturer in Physical Chemistry, Mark Wallace, commented: “The idea of the project is to give students a better understanding of science and what it is like to be a scientist. It’s a great opportunity to genuinely engage with students, talking to them one to one, and hopefully inspiring them to think about becoming a scientist in the future.” Mark’s session of ‘I’m a Scientist, Get me out of here’ takes place from 10-21 March with eight themed zones, four general zones 60 scientists, and nearly 140 different schools from Shetland to Cornwall taking part.

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On the cover of TetrahedronOn the cover of Tetrahedron

A review by Professor David Hodgson and Dr Andrew Charlton on 'Methods for Direct Generation of α-Alkyl-Substituted Aldehydes' has been highlighted on the cover of Tetrahedron. Many paths, one destination. The figure highlights some of the reviewed Csp3−Csp3 asymmetric bond-forming processes that, by overall formal nucleophilic substitution, result in an electrophile losing a leaving group and becoming attached at the α-carbon of an aldehyde.

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Three papers in PNASThree papers in PNAS

Work by the Loenarz and Schofield groups, published as three back-to-back papers in PNAS, identifies novel oxygenase catalysed modifications to ribosomes, in organisms ranging from yeasts to flies and humans. Inhibition of the discovered prolyl hydroxylations can affect the accuracy of protein synthesis, and lead to increased read-through of premature stop codons, including some of clinical relevance (e.g. for Duchenne muscular dystrophy). The work has been conducted in collaboration with Peter Ratcliffe, Matt Cockman (Oxford Medicine) and Pablo Wappner (Argentina).

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ACS Editors’ ChoiceACS Editors’ Choice

The research paper by Steve Davies et al. describing the first asymmetric synthesis and absolute configuration assignment of the marine natural product (−)-nakinadine A, published in Organic Letters, has been selected to be featured in ACS Editors’ Choice.

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DR HONORIS CAUSA DR HONORIS CAUSA

On the 21st February 2014 the University of Salamanca conferred the degree DR HONORIS CAUSA on Professor Steve Davies. Steve is only the third chemist to receive this award, the previous two recipients being Sir Derek Barton (1995) and Steve Ley (2005). The University of Salamanca is one of the oldest universities in the world and only awards three honorary doctorates per year.

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David Clary elected Einstein Professor of Chinese Academy of SciencesDavid Clary elected Einstein Professor of Chinese Academy of Sciences

Professor David Clary has been elected Einstein Professor of the Chinese Academy of Sciences. This award is made to distinguished international scientists working at the frontiers of science and technology. Professor Clary will give lectures associated with his award in Dalian and Beijing in March 2014. More details of the Einstein Professorship can be found here

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Oxford Chemistry highlighted at the 79th Israeli Chemical Society MeetingOxford Chemistry highlighted at the 79th Israeli Chemical Society Meeting

A cross-departmental delegation from Oxford Chemistry were invited to attend the 79th ICS meeting in Tel Aviv, February 4-5 2014. The meeting featured talks by Veronique Gouverneur, Harry Anderson, Tim Softley, Darren Dixon, Andy Weller, Tim Claridge and Andy Baldwin and was attended by the British Ambassador to Israel. The Oxford team were all made honorary life members of the Israeli Chemical Society.

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Henry Moseley seminar by Prof. Russ EgdellHenry Moseley seminar by Prof. Russ Egdell

The ICL seminar on the 11th Feb 2014 was given by Prof. Russ Egdell from our department, on "Henry Moseley: The Centenary of X-ray spectroscopy and the modern form of the Periodic Table"

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€85 million European programme targets novel antibiotics – ENABLE project€85 million European programme targets novel antibiotics – ENABLE project

Oxford Chemistry is pleased to announce the project, which includes over 30 European universities, research institutes and companies, led by GlaxoSmithKline and Uppsala University. The consortium is joining forces in the 6 year project called ENABLE (European Gram-Negative Antibacterial Engine), supported by the Innovative Medicines Initiative (IMI) to develop novel antibiotics against Gram-negative pathogens. It has the mission to complete phase 1 clinical trials of at least one novel anti-bacterial for Gram-negative infections by 2019 and includes open calls for candidates outside the consortium.

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Research highlighted in Chemical and Engineering News and Chemistry WorldResearch highlighted in Chemical and Engineering News and Chemistry World

A paper describing new functional materials that allow conversion of light into macroscopic helical motion has been published by Stephen Fletcher in collaboration with the Nathalie Katsonis Group at the University of Twente, the Netherlands. The article was recently appeared in Nature Chemistry and has been highlighted in Chemistry World and C&E News - the later article includes a 2 minute video showing how these springs mimic motions used by cucumber tendrils to help the plant reach the sun.

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Syngenta ScholarshipsSyngenta Scholarships

Ed Emmett from the Willis group has been awarded one of two Syngenta Scholarships for final year PhD students. Syngenta runs an annual Scholarship Scheme at Jealott’s Hill for organic chemists in the final year of their PhD. Last year’s scholarship scheme consisted of a two day interactive workshop centred on synthetic chemistry and the design of new active ingredients. Syngenta is delighted to announce the 2013 Scholars, who were each awarded a scholarship of £1,000 as well as funding of up to £1,000 to attend a scientific conference of their choice.

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Chemistry World highlights Professor Tom Brown's researchChemistry World highlights Professor Tom Brown's research

Human cells can still read strands of DNA correctly if they are stitched together using linkers not found in nature, a new study by a team including Oxford University researchers shows. The artificially linked DNA was created by joining oligonucleotides using a synthesis technique known as ‘click chemistry’. Previously, authors of the report [in Angewandte Chemie], Ali Tavassoli of the University of Southampton and Tom Brown at the University of Oxford and colleagues, showed that click-linked DNA was correctly read by Escherichia coli bacteria.

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Poster Prize for Alex SmithPoster Prize for Alex Smith

Alex Smith, working in the Perkin group, has won the first prize in the poster competition at the International Nanotribology Forum held in Kerala, India, in January 2014. Alex's work describing the quantized nature of friction forces across liquid films has also been published in PCCP

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Focus on PhosphoproteomicsFocus on Phosphoproteomics

Shabaz Mohammed helps create compilation of key phosphoproteomics research. One of the most abundant, and important, modifications to proteins is phosphorylation. The exquisite specificity of phosphorylation reactions creates regulatory and signalling processes within cells by transfer of phosphate along pathways of proteins. The analytical challenge of deciphering protein phosphorylation is great as the presence of phosphorylation first needs to be detected and then the site of phosphorylation within a protein needs to be determined. Shabaz alongside John Yates of the Scripps Institute and Albert Heck from Utrecht University have created a virtual issue (in the ACS journals Analytical Chemistry and the Journal of Proteome Research) comprising of key papers published over the last decade that have described technologies that are now mainstream biochemical tools. They also highlight new works that have the potential of further accelerating the speed at which we can understand cellular behaviour.

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