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Highlighted on Journal of Experimental Medicine Highlighted on Journal of Experimental Medicine

A research paper by the Professor O'Hare group has been highlighted in the editorial of the Journal of Experimental Medicine. The paper shows that the immunological responses induced by members of a broad class of inorganic crystalline materials are controlled purely by their physicochemical properties in a highly predictable manner. The structurally and chemically homogeneous layered double hydroxides (LDHs) can elicit diverse human dendritic cell responses in vitro. Using a systems vaccinology approach, the work finds that every measured response can be modeled using a subset of just three physical and chemical properties for all compounds tested. This correlation can be reduced to a simple linear equation that enables the immunological responses stimulated by newly synthesised LDHs to be predicted in advance from these three parameters alone. Also shown is that mouse antigen–specific antibody responses in vivo and human macrophage responses in vitro are controlled by the same properties, suggesting they may control diverse responses at both individual component and global levels of immunity. The study demonstrates that immunity can be determined purely by chemistry and opens the possibility of rational manipulation of immunity for therapeutic purposes.

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On the Cover of NatureOn the Cover of Nature

Professor Dame Carol Robinson research article has been highlighted on the cover of Nature. The cover illustrates IM-MS as it captures a native membrane protein complex emerging from an ion mobility cell. Shown is the ammonia channel in apo, one- and two-lipid bound states. The cover was designed by Art Laganowsky.

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Oxford Mail Highlights ExhibitionOxford Mail Highlights Exhibition

The Oxford Mail has highlighted that the department is running the exhibition throughout June to celebrate the United Nation’s International Year of Crystallography. The exhibition shows visitors crystals at the atomic level, and how they are used in dyes, medicines, minerals and sugar.

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2014 Chemistry World Entrepreneur of the Year2014 Chemistry World Entrepreneur of the Year

Tom Brown is The 2014 Chemistry World Entrepreneur of the Year. He is founder of three successful companies on the chemistry/biology interface (Oswel, Primer Design and ATDBio) and is co-inventor of a number of DNA-based techniques for genetic and forensic analysis.

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OUSU Teaching AwardsOUSU Teaching Awards

The excellent teaching of three members of the department - Fabrice Birembaut, Andrew Goodwin, and Martin Galpin - was highlighted at the annual Oxford University Student Union teaching awards ceremony Tuesday 27th May, in the presence of the Vice Chancellor. The three were nominated by students, and shortlisted for the awards from a very long list of nominations by OUSU. Congratulations to all three for this recognition of their valuable contribution to high quality Chemistry teaching.

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Oxford Mail highlights Chemistry's efforts towards the Green Impact schemeOxford Mail highlights Chemistry's efforts towards the Green Impact scheme

The Oxford Mail has an article about the Department's workplace environment. The opportunity arose because the university’s environmental sustainability team launched the National Union of Students (NUS) Green Impact scheme. This is an initiative designed to encourage departments to work towards delivering environmentally friendlier practices. The Green Impact scheme centres on a workbook of criteria which each department must aim to meet in order to obtain awards – starting with bronze, then progressing to silver and gold. (Photo Oxford Mail, Damian Halliwell)

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HOT Article in Organic & Biomolecular ChemistryHOT Article in Organic & Biomolecular Chemistry

Andreas Glawar [Fleet group] is the corresponding author in a collaborative project with the Glycobiology Institute in Oxford and the University Hospital in Toyama which describes the definitive evaluation of pyrrolidine analogues of N-acetylglucosamine and N-acetylgalactosamine as inhibitors of N-acetylhexosaminidases this paper has been selected to be featured as a HOT article in Organic & Biomolecular Chemistry.

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GT Young 1915-2014 - Aldrichian PraelectorGT Young 1915-2014 - Aldrichian Praelector

We are sad to report that Geoffrey Young died at home in Oxford on 24 May 2014, aged 98. Geoffrey was a Fellow of Jesus 1947-1982 and Lecturer in Organic Chemistry 1950-1970 then Aldrichian Praelector in Chemistry 1970-1982. He was a pioneer in peptide chemistry. When funeral arrangements are known we will circulate them.

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NEW YORK TIMESNEW YORK TIMES

An article in the New York Times has highlighted recently published work from the Compton Group ( Int. J. Electrochem. Sci., 9 (2014) 1132 - 1138) which suggests an explanation for the toxicity of silver nanoparticles over that of bulk silver metal (Photo: Ferro Corp.)

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Carol Robinson’s work recognised by international awards:Carol Robinson’s work recognised by international awards:

Carol Robinson has been awarded the 2014 Kaj Linderstrøm-Lang Prize in recognition of her pioneering and outstanding research in the field of structural biology, with particular emphasis on protein complexes. The prize is awarded every three years to scientists with outstanding achievements within biochemistry or physiology, the fields of science in which Professor Kaj Linderstrøm Lang distinguished himself as a pioneer. The award ceremony takes place later this year. This year Carol will also receive the 2014 Thomson Medal Award from the International Mass Spectrometry Foundation. The Thomson Medal Award was established as an acknowledgement of exemplary contributions through outstanding research and distinguished service in mass spectrometry.

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On the Cover of NatureOn the Cover of Nature

A collaboration between Peter Hore and Henrik Mouritsen (University of Oldenburg) has been featured on the cover of Nature. The research covers the surprise observation that night-migratory songbirds (European robins) tested in wooden huts on the University of Oldenburg campus were unable to orient in the appropriate migratory direction using their magnetic compass. Mouritsen and colleagues performed controlled experiments to establish what was happening. They found that robins lose the ability to use the Earth's magnetic field when exposed to low-level AM electromagnetic noise between around 20 kHz and 20 MHz, the kind of noise routinely generated by consumer electrical and electronic equipment. Interestingly, the magnetic component of this electromagnetic noise is a thousand times weaker than the lower exposure limits adopted in current World Health Organization (WHO) guidelines, yet it can disrupt the function of an entire sensory system in a higher vertebrate. The birds regain the ability to orient to the Earth's magnetic field when they are shielded from electromagnetic noise or when tested in a rural setting. The cover illustration was designed by Nature Publishing and Dr Karl Harrison.

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Synthesis of new high temperature superconductorsSynthesis of new high temperature superconductors

Collaboration between the groups of Simon Clarke and Dermot O'Hare, the Diamond Light Source and the ISIS spallation neutron source is highlighted by Diamond. A new iron-based high temperature superconductor was discovered in the course of developing means to follow the intercalation reactions of iron selenide in liquid ammonia.

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Google Doodle for Dorothy HodgkinGoogle Doodle for Dorothy Hodgkin

Google has celebrated the British chemist Dorothy Hodgkin with a Doodle on its homepage. Hodgkin, born 12 May 1910, was awarded the Nobel Prize in Chemistry for discovering the molecular structure of vitamin B12, making her at the time only the third woman to win the prize. She was best known for advancement of the technique of of X-ray crystallography, in which she used large punch-card operated tabulators, early predecessor to the modern computer, to analyse the patterns cast by reflected X-rays. She used to technique to work out the structure of the penicillin molecule, in 1946. This is the molecule shown in the Google Doodle - an image based on Hodgkin's model, which is on display in the Science Museum in London.

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National Chemical Landmark Award celebrates the 50th Anniversary of Dorothy Crowfoot Hodgkin's Nobel Prize in ChemistryNational Chemical Landmark Award celebrates the 50th Anniversary of Dorothy Crowfoot Hodgkin's Nobel Prize in Chemistry

The Royal Society of Chemistry has awarded a new National Chemical Landmark blue plaque to the University of Oxford Inorganic Chemistry Laboratory, to celebrate the 50th anniversary of Britain's only female Nobel Prize winner and to coincide with the UN International Year of Crystallography 2014.

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Macmillan Cancer Support fundraising by Chemistry KeytonesMacmillan Cancer Support fundraising by Chemistry Keytones

The Keytones concert and cake sale raised a fantastic £413.50 for Macmillan Cancer Support. Thank you to everyone who helped make this possible and came along to support us. If you would still like to make a donation you can do so at www.justgiving.com/TheKeytonesSingForMacmillan

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RSC Joseph Black Award 2014 WinnerRSC Joseph Black Award 2014 Winner

Professor Shabaz Mohammed has been awarded the RSC Joseph Black Award 2014 for his seminal contributions to the teaching and practice of analytical chemistry and his inventive developments in chromatographic separations and proteomic characterisation. Shabaz is a Associate Professor of Proteomics in the Departments of Chemistry and Biochemistry. He is also a theme leader at the Netherlands Proteomics Centre and maintains a 'guest' lecturer status at Utrecht University.

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RSC Charles Rees Award 2014 WinnerRSC Charles Rees Award 2014 Winner

Professor Tim Donohoe has been awarded the RSC Charles Rees Award 2014 for his multiple contributions to modern heterocyclic chemistry. Tim's research interests lie in the field of heterocyclic chemistry, catalysis and the synthesis of natural products. He also has a burgeoning interest in the area of hydrogen borrowing and the application of new catalytic reactions to the synthesis of aromatic systems. In 2001 he moved to the Dyson Perrins Laboratory, Oxford as Lecturer in Chemistry and Fellow of Magdalen College. In 2004 he was appointed Professor of Chemistry at the University of Oxford and he was Head of Organic Chemistry at Oxford between 2006 and 2011.

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RSC Catalysis in Organic Chemistry Award 2014 WinnerRSC Catalysis in Organic Chemistry Award 2014 Winner

Professor Michael Willis has been awarded the RSC Catalysis in Organic Chemistry Award 2014, for innovations in catalytic methodology in organic synthesis applied towards C-C bond formation and the assembly of heterocycles. In January 2007 he moved to the University of Oxford, where he is now a Professor of Chemistry and Fellow of Lincoln College. He was awarded an EPSRC Advanced Research Fellowship in 2005, an Established Researcher Fellowship in 2013, and the 2008 AstraZeneca Research Award for Organic Chemistry. His group's research interests are based on the development and application of new catalytic processes for organic synthesis.

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Poster prize for Zilei LiuPoster prize for Zilei Liu

Zilei Liu (Fleet group) won a poster prize at the RSC Carbohydrate Spring meeting in Bath on April 31-1 May for his presentation titled: Short and Sweet Approaches to Large Scale Syntheses of L-Glucose and D-Gulose from D-Glucose, by an approach that gives easy access to otherwise expensive and inaccessible sugars. Some of this work is described in Angew. Chem. Int. Edit. 2014, 53, 1160-1162.

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Thesis commendationThesis commendation

Rob Turbervill's D.Phil. thesis on the reactivity of anionic main-group cluster cages has received a commendation from MPLS division. This achievement has been highlighted on the Wadham college webpage. The thesis entitled Solution Reactivity Studies of Group 15 Zintl Anions Towards Unsaturated Substrate was praised atruly outstandin by the D.Phil. examiners and as exceptional by MPLS division. Rob is currently working as a PDRA in the Goicoechea group funded by an EPSRC Doctoral Prize award.

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Professor Peter Edwards elected to the American Academy of Arts and Sciences.Professor Peter Edwards elected to the American Academy of Arts and Sciences.

Peter Edwards, Professor of Inorganic Chemistry and Fellow of St Catherine's College, has been elected among the class of 2014 as Foreign Honorary Members. One of America's most prestigious honorary societies, the Academy is also a leading centre for independent policy research. Members contribute to Academy publications and studies of science and technology policy, energy and global security, social policy and American institutions, and the humanities, arts and education. Professor Edwards is a Fellow of the Royal Society and a Member of the German Academy of Sciences, Leopoldina, and Einstein Professor of the Chinese Academy of Sciences. In 2003 he was awarded the Royal Society's Hughes Medal and in 2012 gave its Bakerian Lecture. He said: 'This really is a dream for me to receive such a tremendous honour. I am absolutely delighted and feel truly privileged to be elected to the Academy.' Since its founding in 1780, the Academy has elected leading 'thinkers and doers' from each generation, including George Washington and Benjamin Franklin in the 18th century, Daniel Webster and Ralph Waldo Emerson in the 19th, and Margaret Meade and Martin Luther King Jr in the 20th. The current membership includes more than 250 Nobel laureates and more than 60 Pulitzer Prize winners.

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OxSyBio - New Oxford Chemistry Spin-OutOxSyBio - New Oxford Chemistry Spin-Out

A new University of Oxford spin-out, OxSyBio, will develop 3D printing techniques to produce tissue-like synthetic materials for wound healing and drug delivery. In the longer term the company aims to print synthetic tissues for organ repair or replacement. Isis Innovation, the University's research commercialisation company announced today that OxSyBio has raised 1 million from IP Group plc, the developer of intellectual property based businesses, subject to the achievement of milestones. The new company will refine and advance the 3D droplet printing technology devised by Professor Hagan Bayley's group at the University's Department of Chemistry. (Printed droplet networks c.500 microns across [Credit: Oxford University/A Graham].

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Research highlighted in Angewandte ChemieResearch highlighted in Angewandte Chemie

A recent paper by Andrew Jupp and Jose Goicoechea has been highlighted in Angewandte Chemie. The original article, which was published in the Journal of the American Chemical Society late last year, described the synthesis of a phosphorus-containing analogue of urea (phosphinecarboxamide). The Angewandte Highlight raises interesting questions regarding the influence of "heavy" p-block elements on the physical and chemical properties of relatives of well-established organic molecules. It concludes that the compound offers "great potential for the development of innovative applications or new synthetic pathways that may pave a way to further exciting molecules”.

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Hot Article in AnalystHot Article in Analyst

The paper "Nanoparticles in Sensing Applications: On What Timescale Do Analyte Species Adsorb on the Particle Surface?" by Enno Katelhon and Richard G. Compton has been selected as a hot article.

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On the cover of Chemical Physics LettersOn the cover of Chemical Physics Letters

For the second time in March 2014 a paper from the Compton group is featured on the cover of Chemical Physics Letters! The most recent is a 'Frontiers Article' entitled 'Simultaneous electrochemical and 3D optical imaging of silver nanoparticles' by Christopher Batchelor-McAuley, Kristina Tschulik and Richard Compton together with collaborators from Paris, France.

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CrystEngComm cover and Hot ArticleCrystEngComm cover and Hot Article

A study by DPhil student Ines Collings has been highlighted on the cover of CrystEngComm. Ines's work develops a simple rule that allows the mechanical behaviour of framework materials to be predicted based only on their geometry and was selected by the journal editors as February's top 'Hot Article'

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HOT Article in Organic & Biomolecular ChemistryHOT Article in Organic & Biomolecular Chemistry

The research paper by Steve Davies et al. describing the asymmetric synthesis of C(5)-substituted transpentacins via a diasereoselective Ireland Claisen protocol has been selected to be featured as a HOT article in Organic & Biomolecular Chemistry.

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Inorganic Chemistry Graduate Symposium and 2014 Malcolm Green LectureInorganic Chemistry Graduate Symposium and 2014 Malcolm Green Lecture

The Inorganic Chemistry Graduate Symposium took place on 25th - 26th March. This featured excellent research presentations by 33 final year graduate students across the full range of inorganic chemistry. The Symposium culminated in the 2014 Malcolm Green Lecture, presented by Professor Harry B Gray from the California Institute of Technology (pictured with Malcolm Green, Professor and Head of Inorganic Chemistry until 2003), and his lecture was entitled "Solar-Driven Water Splitting".

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On the Cover of Angewandte ChemieOn the Cover of Angewandte Chemie

In a communication A. D. Hamilton, S. Thompson, et al. reveal a strategy for mediating β-sheet interactions through the use of a tetrasubstituted diphenylacetylene to induce the formation of β-sheet structures in two directions. β-Sheets, key secondary structural elements of folded proteins, are commonly involved in therapeutically important protein–protein interactions and are a critical constituent of amyloid deposits in many neurodegenerative conditions. (illustration by Dr. Karl Harrison).

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COVER OF CHEMICAL PHYSICS LETTERSCOVER OF CHEMICAL PHYSICS LETTERS

The cover of the March 18th issue of CPL features an article entitled "Equality of diffusion-limited chronoamperometric currents to equal area spherical and cubic nanoparticles on a supporting electrode surface" authored by Enno Kaetelhoen, Eddy Barnes and Richard Compton together with collaborators from Julich, Germany. The image was created by Enno

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