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Hot paper in Angewandte ChemieHot paper in Angewandte Chemie

The paper 'Elecgtrochemical sizing of organic nanoparticles' by Wei Cheng, Xiao-Fei Zhou and Richard G Compton has been selected as a 'hot paper' by the editors of Angewandte Chemie. For details please see:

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Eisai Prize-winning ceremonyEisai Prize-winning ceremony

Congratulations to Joseph Lawrence, Gavin Young, David Ascough, Watcharaphol Paritmongkol (Oat) and Constantin Giurgiu on receiving prizes for the outstanding results in their 2nd year undergraduate exams. The event took place on 16 October and the prizes were presented by Dr. Adrian Hall of Eisai Limited.

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New Chemistry Spin-Out  Oxford BiotransNew Chemistry Spin-Out Oxford Biotrans

The latest University spinout Oxford Biotrans, will commercialise new routes to high-value chemicals using patented enzyme technology. The first products to market will be natural flavours and fragrances. The technology comes out of the Oxford Chemistry Department. Dr Luet Wong, the inventor, explained: “The technique makes use of enzymes to transform commonly available natural extracts into our target flavour and fragrance compounds. The process requires little energy and generates almost no waste in contrast to conventional chemical processes. The real benefit is that the end product is completely natural.”

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AstraZeneca Organic Chemistry & Chemical Biology DPhil symposiumAstraZeneca Organic Chemistry & Chemical Biology DPhil symposium

Congratulations to Christopher Pearson, Matthew Robinson, Charlotte Richards-Taylor and Rok Sekernik on receiving prizes for the best presentations at the final year DPhil symposium sponsored by AstraZeneca and presented by their scientists Jeremy and Hitesh.

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Poster Prize for Duncan HayPoster Prize for Duncan Hay

Duncan Hay from the Schofield group won best poster at the 17th RSC/SCI Medicinal Chemistry Symposium which took place from the 8th to the 11th of September. His poster was entitled “Reader’s Block: Discovery of an Epigenetic Chemical Probe for CBP/p300 Bromodomains.”

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Singapore Company Manufactures Oxford Chilli TesterSingapore Company Manufactures Oxford Chilli Tester

A chilli sensor developed in the Professor Richard Compton's group at the University of Oxford is to be manufactured by Singapore spin-out, Bio-X (S) Pte. Ltd. to bring standardisation for heat in the food industry. The mass-produced sensor could see the ubiquitous chilli symbols on food packaging replaced by Scoville units. The sensor measures the levels of capsaicinoids, chemicals in chillies that gives us the characteristic ‘heat’. The most common method of assessing the heat at the moment involves a panel of tasters – which takes time, incurs costs and often yields variable results.

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On the cover of RSC's OBCOn the cover of RSC's OBC

Andreas Glawar designed the illustration to show the collaboration between the Fleet group in Oxford with the Japan groups of Ken Izumori in Takamatsu and Atsushi Kato in Toyama. The paper reports the synthesis by clean green chemistry combined with biotechnology to make all 16 stereoisomers of HNJ with 5 chiral centers - and their biological evaluation. 6 of them are natural products, all of which were made before they were isolated. The article was part of themed collection: J400: Celebrating the 400th year of Japan-UK relations.

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On the cover of RSC's Chemical ScienceOn the cover of RSC's Chemical Science

Research by Jacob Bush and co-workers in Professor Christopher Schofield's group has been h highlighted on the cover of RSC's Chemical Science. The paper describes the use of the Ugi four-component reaction (U-4CR) for the expedient and versatile assembly of photoaffinity scaffolds that can be linked to small molecule probes. The rates, yields and sites of crosslinking of five commonly used photoreactive groups comprising diazirines, aryl azides and a benzophenone, were compared using a human 2-oxoglutarate oxygenase as a model protein. The results reveal significant differences in the behavior of the probes and suggest that empirically guided optimization of probes for specific tasks is desirable.

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Spectrometer design by Professor John Eland highlightedSpectrometer design by Professor John Eland highlighted

The SLAC National Accelerator Laboratory, California has highlighted the work by Professor John Eland using a new technique that traces ejected electrons back to atomic shells. Uppsala University's Melanie Mucke, Uppsala Professor Raimund Feifel and Professor John Eland at University of Oxford and a guest professor at Uppsala, stand by a 2-meter-long magnetic bottle time-of-flight spectrometer, dubbed FELCO (for Free-Electron Laser Correlation), whose design is based on the pioneering concept of Eland. The spectrometer is named for its milk bottle-like arrangement of magnetic fields. Researchers used FELCO for experiments at the SLAC's Linac Coherent Light Source X-ray laser and Atomic, Molecular and Optical Science (AMO) instrument

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Best Young Researcher TalkBest Young Researcher Talk

Jonathan Quinson was joint winner of the ‘Best Talk from Young Researchers’ at the HeteroNanoCarb2013 meeting in Barcelona, 22-26 September. Jonathan is conducting his DPhil research jointly between Nicole Grobert’s group in Materials and Kylie Vincent’s group in Chemistry.

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Win win at the Syngenta collaborative research conferenceWin win at the Syngenta collaborative research conference

DPhil students Iacovos Michaelides and Alex Deeming from the Dixon and Willis groups respectively have both been awarded prizes at the Syngenta collaborative research conference held at Syngenta’s Jealott's Hill International Research Centre on the 5-6th of September. Iacovos won 1st prize for his talk titled “Towards the total synthesis of daphniyunnine D” and Alex won 2nd prize for his poster presentation titled “Application of DABSO towards the synthesis of sulfones and sulfonamides”.

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Poster Prize for Holly ReevePoster Prize for Holly Reeve

DPhil student Holly Reeve in the Vincent group won the poster prize at the RSC Biotechnology Group conference on 'High Value Chemicals from Biomass' in London on 17 September.

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Mr Alan Howe Senior Organic Chemistry Teaching Support Technician Mr Alan Howe Senior Organic Chemistry Teaching Support Technician

Alan Howe retired on 31 August after more than 40 years as a Technician in the Department of Chemistry. A reception was held on Friday 30 August to celebrate Alan’s time in the Department and to say goodbye to an exceptional member of staff who has made an enormous contribution to the smooth running of the teaching labs over several decades. Alan will be greatly missed by his colleagues and the many students he taught, inspired, and nursed.

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On the cover of  RS Interface FocusOn the cover of RS Interface Focus

A review by Christiane Timmel and colleagues on the 'Magnetic field effects in flavoproteins and related systems' has been highlighted on the cover of the Royal Society's journal Interface Focus. The image by Charlotte Dodson shows the PHR domain of Drosophila cryptochrome (grey-blue; PDB 4GU5) with C-terminal extension (dark pink) and tryptophan triad (orange). The article appeared in a themed issue of the journal on 'Photons and biology' which was organized by Fraser A. Armstrong.

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In Celebration of Andrew D. Hamilton’s Career in ChemistryIn Celebration of Andrew D. Hamilton’s Career in Chemistry

The RSC has produced a themed collection of articles that have been dedicated to Professor Andrew D. Hamilton FRS, Vice-Chancellor of the University of Oxford, on the occasion of his 60th birthday. Featuring over 40 contributions from students and colleagues past and present, and an introductory Profile article by guest-editors Sam Thompson and Andrew J. Wilson, with the contribution of Sir Alan R. Battersby.

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Prize at PET Chemistry UK 2013Prize at PET Chemistry UK 2013

Dr Matthew Tredwell (Gouverneur Group) won the first prize for the best oral communication at the PET Chemistry UK 2013 Meeting that took place on the 4th September at Newcastle.

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Poster Prize for Zilei LiuPoster Prize for Zilei Liu

Zilei Liu (Professor Fleeet group) won a joint prize for the best poster at the 1st Joint RSC Fluorine-Carbohydrate subject meeting at Southampton on 2/3 September - his poster was entitled "Synthesis of Novel Fluoro Iminosugars and Fluoro Proline Analogue".

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On the cover of Trends in Biochemical SciencesOn the cover of Trends in Biochemical Sciences

The review in this month's TiBS by Charlotte Dodson, Peter Hore and Mark Wallace on cryptochrome magentoreception inspired the journal to commission cover artwork from Abid Javed (www.abidsbrushstrokes.com and @sunshine_6). Migratory birds and other animals are thought to take advantage of the spin chemistry occuring in cryptochrome proteins to sense the direction of the Earth's magnetic field and find their way over thousands of miles

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Physics Today highlights research using the PImMS cameraPhysics Today highlights research using the PImMS camera

Physics Today highlights research using the PImMS camera, a fast CMOS-based imaging camera developed in the groups of Andrei Nomerotski (formerly in Oxford Physics, now at Brookhaven National Laboratory, USA) and Renato Turchetta (the Rutherford Appleton Laboratory), in collaboration with those of Claire Vallance and Mark Brouard in Oxford Chemistry. The research highlighted, from the group of Michael White and colleagues at Brookhaven National Laboratory and Stony Brook University, USA, uses the PImMS camera to measure photofragment angular distributions subsequent to a surface catalysed photoreaction.

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Alfred Tissières Award for Justin BeneschAlfred Tissières Award for Justin Benesch

Cell Stress Society International have presented the Alfred Tissières Award to Justin Benesch for his research into the biophysics underpinning molecular chaperone function. The award is named after one of the pioneers of the heat shock and cell stress field, includes a book describing the 1954 British expedition to Rakopashi, an iconic peak in the Karakoram, that he led.

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Honorary Doctorate for Professor Gus HancockHonorary Doctorate for Professor Gus Hancock

Professor Gus Hancock has been awarded an Honorary Doctorate by The University of Córdoba. The University, which has over 100,000 students, is the oldest in Argentina, founded in 1613, and the 400th anniversary celebrations this year coincided with the 30th anniversary of the founding of the Physical Chemistry Department. Professor Hancock has lectured regularly in the Department for the past 15 years, and has hosted several visitors from Argentina to the PTCL during that time. He was presented with the degree by the Rector of the University, Dr Francisco Tamarit.

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New York Academy of Sciences 'Future Leader'New York Academy of Sciences 'Future Leader'

The New York Academy of Sciences has selected Andrew Goodwin as one of ten 'Future Leaders' in Science to attend the Science and Technology in Society (STS) forum, held in Kyoto in October. The annual forum brings together key players in the academic, scientific, political and business arenas to discuss the promises and risks of science and technology, and how they impact on society.

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Inside Cover of Chem CommInside Cover of Chem Comm

A collaboration between Carol V. Robinson and Jasmin Mecinovic (Institute for Molecules and Materials, Radboud University Nijmegen) showed using a combination of size exclusion chromatography, multi-angle laser light scattering, and mass spectrometry revealed that the unusual catenane structure of CS2 hydrolase is not an artefact. The cover was designed by Karl Harrison.

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On the Cover of JOCOn the Cover of JOC

Jason Sengel working with George Fleet has created an illustration based on Tenniel's original drawing, Alice is about to go through the mirror. Alice is worried for her kittens how looking-glass milk (with D-amino acids and L-sugars) will taste, but even cats know L-glucose is as sweet as D-glucose. Curiously, both enantiomers of iminosugars often inhibit the same enzymes. Simple five- and six-carbon pyrrolidines have significant but unpredictable bioactivities, not all due to glycosidase inhibition

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Hot Paper in Angewandte ChemieHot Paper in Angewandte Chemie

A paper by Heather Johnson in the Weller group has been selected as a Hot Paper in Angewandte Chemie. It reports B-B bond formation through the dehydrogenative homocoupling of an amine-borane on a Rh(I) centre.

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On the cover of Nature ChemistryOn the cover of Nature Chemistry

was shown an eight-fold symmetrical cyclodextrin-based inhibitor binding to the octameric channel-forming protein Wza, discovered by Dr Lingbing Kong and Dr Leon Harrington in Ben Davis and Hagan Bayley group. A News and Views article particularly highlighted the adaptation and application of an electrochemical sensing technique to the discovery of the first examples of inhibitors against an important new class of antimicrobial drug target. It is also predicted that once the high throughput is achieved with the nanopore-based DNA sequencing, the screening of inhibitors against microbial transporters could be truly transformative

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Highlighted in C&ENHighlighted in C&EN

A paper by Jamie Woltenshulme and co-workers in the Gouverneur group published in Angewandte Chemie has been highlighted in Chemical and Engineering News. The article describes a new generation of chiral Selectfluor reagents for the preparation of enantioenriched helical shaped fluorinated tetracyclic compounds .

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Wired magazine highlights DPhil researchWired magazine highlights DPhil research

Andrew Cairns's discovery of a material that expands under pressure is the focus of a news article in the US tech magazine 'Wired' - the online version of which attracts an impressive 19 million unique visitors each month. The strange behaviour of Andrew's material arises from a combination of supramolecular 'springs' that absorb the 'shock' of increased pressure and a nifty geometry that converts rapid compression in one direction into a strong expansion in another direction. Now coming to the end of the second year of his DPhil in the Goodwin group, Andrew published his key results in Nature Materials earlier this year.

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Symposium Prizes for Stefan Verhoog and Miriam O'DuillSymposium Prizes for Stefan Verhoog and Miriam O'Duill

Two D Phil Students (Gouverneur group) win Poster Prizes at the 18th European Symposium on Organic Chemistry (ESOC 2013) in Marseille, France July 7-13, 2013. Stefan Verhoog received one of the three Wiley EurJOC Poster Awards and Miriam O' Duill received one of the 9 posters Awards sponsored by Syngenta. Both presented their recent work on catalytic trifluoromethylation of allylsilanes and unactivated alkenes.

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American Crystallographic Association Lecturer AwardsAmerican Crystallographic Association Lecturer Awards

Karim Sutton (Cooper Group) and Andrew Cairns (Goodwin Group) have been awarded Margaret C. Etter Student Lecturer Awards at the recent American Crystallographic Association Annual Meeting in Honolulu. Karim presented recent work on the application of macromolecular phasing techniques to small molecule crystallography, while Andrew spoke on designing new materials with large negative linear compressibility. Every year one winner is selected by each scientific interest group of the ACA.

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