Publications
Reviews
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1-Aminocyclopropane-1-carboxylate oxidase: molecular structure and catalytic function
John P, Iturriagagoitiabueno T, Lay V, Thomas PG, Hedderson TAJ, Prescot AG, Gibson EJ, Schofield CJ Biology And Biotechnology Of The Plant Hormone Ethylene (Ed. Kamellis AK),
1997, 1-9 (Kluiver Academic Publishers, Dordrecht).
Studies on the reactivity of azetidin-2-ones in phosphate buffer
Westwood NJ, Claridge TDW, Schofield CJ
J. Chem. Soc., Perkin Trans 1 1997, 2725-2729.
Chemistry and biosynthesis of clavulanic acid and other clavams
Baggaley KH, Brown A G, Schofield CJ
Natural Product Reports 1997, 14, 309-333.
Tripeptide Ly301621 and its diastereomers as methicillin potentiators against methicillin resistant Staphylococcus aureus
Eid CN, Halligan NG, Nicas TI, Mullen DL, Butler TF, Loncharich RJ, Paschal JW, Schofield CJ, Westwood NJ, Cheng L-F
Journal Of Antibiotics 1997, 50, 283-285.
Mass spectrometric studies on the inhibition of TEM-2 beta-lactamase by clavulanic acid derivatives
Brown R P, Aplin RT, Frydrych C, Schofield CJ
Journal Of Antibiotics 1997, 50, 184-185.
Synthesis of trifluoromethyl alcohol and ketone inhibitors of metallo beta-lactamases
Walter MW, Adlington RM, Baldwin JE, Schofield CJ
Tetrahedron 1997, 53, 7275-7290.
L-Delta-(alpha-L-aminoadipoyl)-L-cysteinyl-D-valine (ACV) synthetase: thioesterification of valine is not obligatory for peptide bond formation
Shiau C-Y, Byford MF, Aplin RT, Baldwin JE, Schofield CJ
Biochemistry 1997, 36, 8798-8806.
Chemo-enzymatic synthesis of bicyclic gamma-lactams using clavaminic acid synthase
Baldwin JE, Adlington RM, Bryans J S, Lloyd MD, Sewell T J, Schofield CJ, Baggaley K H, Cassels R
Tetrahedron, 1997, 53, 7011-7020.
Structure of a specific acyl-enzyme complex formed from an unmodified peptide and elastase
Wilmouth R C, Robinson C V, Clifton I, Hajdu J, Roach PL, Schofield CJ
Nature Structural Biology 1997, 4, 456-462.
X-Ray absorption spectroscopic studies of the iron(II) active site of clavaminic acid synthase
Baldwin JE, Charnock JM, Garner C D, Fujishima Y, Hassan A, Schofield CJ, Edwards H
Protein Engineering 1997, 10, No.SS, P.45.
Studies on side chain interactions during the isopenicillin N synthase catalysed biosynthesis of penicillins
Cavelier F, Russell A T, Schofield CJ, Baldwin JE
Journal of Chemical Research-S 1997, 200-201.
Chemistry of beta-Lactams
Westwood N J, Thirkettle J, Schofield CJ
Royal Society Of Chemistry, Specialist Periodical Reports, Amino Acids, Peptides And Proteins, 1997, 28, Chapter 6.
Gln-330 is not essential for catalysis by IPNS from Aspergillus nidulans
Sami M, Brown T., Roach PL, Baldwin JE, Schofield CJ
FEBS Letters, 1997, 405, 191-194.
Inactivation of 1-aminocyclopropane-1-carboxylate oxidase involves oxidative modifications
Barlow J N, Zhang Z-H, John P, Baldwin JE, Schofield CJ
Biochemistry, 1997, 36, 3563-3569.
Crystal structure of isopenicillin-N synthase complexed to its tripeptide substrate
Roach PL, Clifton IC, Hensgens, CMH, Shibata N, Schofield CJ, Baldwin JE, Hajdu J
Nature, 1997, 387, 827-830.
The origin of the beta-lactam carbons of clavulanic acid
Thirkettle JE, Baldwin JE, Edwards J, Griffin JP, Schofield CJ
Chemical Communications, 1997, 1025-1026.
An investigation of the N-arylsulfonylation of 2-azetidinones
Adlington RM, Baldwin JE, Mccoull W, Pritchard G J, Schofield CJ, Westwood N J
Synthetic Communications, 1997, 27, 3803-3813.
Structural and mechanistic studies on the reactivity of analogous lactams with elastase
Westwood NJ, Edwards PD, Claridge TW, Schofield CJ
Bioorganic And Medicinal Chemistry Letters, 1997, 7, 2973-2978.
Synthesis of (2S3R,4S), (2S,3S,4R)-epoxyprolines and aminohydroxyprolines
Robinson J K, Lee V, Claridge T W, Baldwin JE, M F, Schofield CJ
Tetrahedron, 1997, 54, 981-996.
The Mechanism of ACV Synthetase
Byford MF, Shiau C-Y, Baldwin JE, Schofield CJ
Chemical Reviews, 1997, 97, 2631-2649.
Metal catalysed oxidation and mutagenesis studies on the iron binding site of ACC oxidase
Zhang Z-H, Barlow J N, Baldwin JE, Schofield CJ
Biochemistry, 1997, 36, 15999-16007.
Substrate analogue and inhibition studies on 1-aminocyclopropane-1-carboxylate oxidase: D- but not L-valine is a substrate yielding iso-butanal
Barlow J N, Zhang Z-H, John P, Baldwin JE, Schofield CJ
Phytochemistry, 1997, 48, 619-624.
Enzymes of penicillin biosynthesis
Schofield CJ Zhang Z-H, Barlow J N, Baldwin JE, Clifton I Byford M F, Roach PL
Current Structural Biology, 1997, 7, 857-864.