Publications


Reviews
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Mutagenesis studies on the iron binding ligands of clavaminic acid synthase
Doan LX, Hassan A, Lipscomb SJ, Dhanda A, Zhang ZH, Schofield CJ
Biochemical And Biophysical Research Communications, 2000, 279, 240-244.


Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase
Dubus A, Llyod MD, Lee HJ, Schofield CJ, Baldwin JE, Frere JM
Cellular and Molecular Life Sciences, 2001, 58, 835-843.


Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS)
Lee HJ, Lloyd MD, Harlos K, Clifton IJ, Baldwin JE, Schofield CJ
Journal of Molecular Biology, 2001, 308, 937-948.


Unnatural co-substrate-based rescue of enzyme activity in Refsum's disease resulting from mutations in R275 of phytanoyl-CoA hydroxylase.
Lloyd MD, Mukherji M, Kershaw N, MacKinnon CH, Schofield CJ, Wierzbicki AS
American Journal Of Human Genetics, 2000, 67, 1642.


Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase
Zhang ZH, Ren JS, Stammers DK, Baldwin JE, Harlos K, Schofield CJ
Nature Structural Biology, 2000, 7, 127-133.


Are anthocyanidins the immediate products of anthocyanidin synthase?
Turnbull JJ, Sobey WJ, Aplin RT, Hassan A, Firmin JL, Schofield CJ, Prescott AG
Chemical Communications, 2000, 2473-2474.


Studies of isopenicillin N synthase enzymatic properties using a continuous spectrophotometric assay
Dubus A, Sami M, Brown TJN, Schofield CJ, Baldwin JE, Frere JM
FEBS Letters, 2000, 485, 142-146.


'pH-Jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexes
Wright PA, Wilmouth RC, Clifton IJ, Schofield CJ
Biochemical Journal, 2000, 351, 335-340.


The reaction of TMS-CF3 with amino acid derived ring-templates: studies with oxazin-2-ones and oxazolidin-5-ones
Walter MW, Thaker N, Baldwin JE, Muller M, Schofield CJ
Journal of Chemical Research-S, 2000, 310-311.


Syntheses of (6S)-cephalosporins from 6-aminopenicillanic acid
Fekne RT, Baldwin JE, Adlington RM, Jones TW, Prout CK, Schofield CJ
Tetrahedron, 2000, 56, 6053-6074.


Reaction of clavams with elastase reveals a general method for inhibiting 'serine' enzymes
Wilmouth RC, Li YH, Wright PA, Claridge TDW, Aplin RT, Schofield CJ
Tetrahedron, 2000, 56, 5729-5733.


Mass spectrometry reveals elastase inhibitors from the reactive centre loop of alpha(1)-antitrypsin
Wright PA, Rostom AA, Robinson CV, Schofield CJ
Bioorganic & Medicinal Chemistry Letters, 2000, 10, 1219-1221.


Oxidative degradation of bilirubin produces vasoactive compounds
Kranc KR, Pyne GJ, Tao LM, Claridge TDW, Harris DA, Cadoux-Hudson TAD, Turnbull JJ, Schofield CJ, Clark JF
European Journal Of Biochemistry, 2000, 267, 7094-7101.


The effect of cysteine mutations on recombinant deacetoxycephalosporin C synthase from S. clavuligerus
Lee HJ, Lloyd MD, Harlos K, Schofield CJ
Biochemical And Biophysical Research Communications, 2000, 267, 445-448.