Publications
Reviews
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Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803
McNeill LA, Hewitson KS, Claridge TD, Seibel JF, Horsfall LE, Schofield CJ
Biochem J 2002, 367: 571-575.
Binding of D- and L-Captopril inhibitors to metallo-beta-lactamase studied by polarizable molecular mechanics and quantum mechanics
Antony J, Gresh N, Olsen L, Hemmingsen L, Schofield CJ, Bauer R
Journal Of Computational Chemistry 2002, 23: 1281-1296
Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis
Elkins JM, Clifton IJ, Hernandez H, Doan LX, Robinson CV, Schofield CJ, Hewitson KS
Biochem J 2002, 366: 423-434
Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal alpha oxidation of phytanic acid
Mukherji M, Kershaw NJ, Schofield CJ, Wierzbicki AS, Lloyd MD
Chemistry & Biology 2002, 9: 597-605
The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase
Lipscomb SJ, Lee HJ, Mukherji M, Baldwin JE, Schofield CJ, Lloyd MD
European journal of biochemistry 2002, 269: 2735-2739
5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition
Migaud ME, Wilmouth RC, Mills GI, Wayne GJ, Risley C, Chambers C, Macdonald SJF, Schofield CJ
Chemical Communications 2002, 1274-1275
Structural basis for the recognition of hydroxyproline in alpha IF-1 alpha by pVHL
Hon WC, Wilson MI, Harlos K, Claridge TDW, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY
Nature 417 (6892): 975-978 JUN 27 2002
X-ray structure of a serine protease acyl-enzyme complex at 0.95 A resolution.
Katona G, Wilmouth RC, Wright PA, Berglund GI, Hajdu J, Neutze R, Schofield CJ
J. Biol. Chem 2002. 277: 21962-21970
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ
J. Biol. Chem 2002, 277: 26351-26355.
ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity
Kershaw NJ, McNaughton HJ, Hewitson KS, Hernandez H, Griffin J, Hughes C, Greaves P, Barton B, Robinson CV, Schofield CJ
European Journal of Biochemistry 2002, 269, 2052-2059.
Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centred rearrangements
Zhang ZH, Ren JS, Harlos K, McKinnon CH, Clifton IJ, Schofield CJ
FEBS Letts 2002, 517, 7-12.
Demonstration of protocadherin X/Y immunoreactive neurones in human cerebral cortex
Priddle TH, Cranfield M, Hewitson KS, Williams NA, Groome NP, Schofield CJ, Esiri MM, Crow TJ
Schizophrenia Research 2002, 53, 68-69 Sp. Iss. SI Suppl. S.
Active site mutations of recombinant deacetoxycephalosporin C synthase
Lee HJ, Schofield CJ, Lloyd MD
Biochemical and Biophysical Research Communications 2002, 292, 66-70.
Enzymatic synthesis of monocyclic beta-lactams
Sleeman MC, MacKinnon CH, Hewitson KS, Schofield CJ
Bioorganic & Medicinal Chemistry Letters 2002, 12, 597-599.
Molecular dynamics simulations of the acyl-enzyme and the tetrahedral intermediate in the deacylation step of serine proteases
Topf M, Varnai P, Schofield CJ, Richards WG
Proteins-Structure Function and Genetics 2002, 47, 357-369.
Refsum's disease: a peroxisomal disorder affecting phytanic acid alpha-oxidation
Wierzbicki AS, Lloyd MD, Schofield CJ, Feher MD, Gibberd FB
Journal of Neurochemistry, 2002, 80, 727-735.
Structure and mechanism of anthocyanidin synthase from Arabidopsis thaliana.
Wilmouth RC, Turnbull JJ, Clifton IJ, Prescott AG Schofield CJ
Structure, 2002, 10, 1-20.