Publications
Reviews
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New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria
McDonough MA, Schofield CJ
Chem Biol 10 (10): 898-900, 2003
The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity
Turnbull JJ, Nagle MJ, Seibel JF, Welford RWD, Grant GH, Schofield CJ
Bioorg Med Chem Lett 13 (21): 3853-3857, 2003
The chemical biology of branched-chain lipid metabolism
Mukherji M, Schofield CJ, Wierzbicki AS, Jansen GA, Wanders RJA, Lloyd MD
Prog Lipid Res 42 (5): 359-376, 2003
2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase
Mole DR, Schlemminger I, McNeill LA, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ
Bioorg Med Chem Lett 13 (16): 2677-2680, 2003
The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding
Damblon C, Jensen M, Ababou A, Barsukov I, Papamicael C, Schofield CJ, Olsen L, Bauer R, Roberts GCK
J Biol Chem 278 (31): 29240-29251, 2003
Structural studies on the reaction of isopenicill in N synthase with the subsrate analogue
delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alpha-aminobutyrate
Long AJ, Clifton IJ, Roach PL, Baldwin JE, Schofield CJ, Rutledge PJ
Biochem J 372: 687-693, 2003
The role of iron and 2-oxoglutarate oxygenases in signalling
Hewitson KS, McNeill LA, Elkins JM, Schofield CJ
BIOCHEM SOC T 31: 510-515, 2003
Crystal structure of carbapenem synthase (CarC)
Clifton IJ, Doan LX, Sleeman MC, opf M, Suzuki H, Wilmouth RC, Schofield CJ
J Biol Chem 278: 20843-20850, 2003
Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases
Schlemminger I, Mole DR, McNeill LA, Dhanda A, Hewitson KS, Tian YM, Ratcliffe PJ, Pugh CW, Schofield CJ
Bioorg Med Chem Lett 13: 1451-1454, 2003
The selectivity and inhibition of AlkB
Welford RWD, Schlemminger I, McNeill LA, Hewitson KS, Schofield CJ
J Biol Chem 278: 10157-10161, 2003
The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase
Lee HJ, Dai YF, Shiau CY, Schofield CJ, Lloyd MD
Eur J Biochem 270: 1301-1307, 2003
Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors
Seibel E, Brown D, Amour A, MacDonald SJ, Oldham NJ, Schofield CJ
Bioorg Med Chem Lett 13 (3): 387-389, 2003
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha
Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ
J BIOL CHEM 278 (3): 1802-1806, 2003