Publications


Reviews
Please select a year:
2010  2009  2008  2007  2006  2005  2004  2003  2002  2001  2000  pre-2000 

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases
Lancaster DE, McDonough MA, Schofield CJ
Biochemical Society Transactions 32: 943-945, 2004


Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity
Lancaster DE, McNeill LA, McDonough MA, Aplin RT, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ
Biochemical Journal 383: 429-437, 2004


Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase - The ethylene-forming enzyme
Zhang ZH, Ren JS, Clifton IJ, Schofield CJ
Chemistry & Biology 11 (10): 1383-1394, 2004


The HIF pathway as a therapeutic target
Hewitson KS, Schofield CJ
Drug Discovery Today 9 (16): 704-711, 2004


The unusual bifunctional catalysis of epimerization and desaturation by carbapenem synthase
Topf M, Sandala GM, Smith DM, Schofield CJ, Easton CJ, Radom L
Journal Of The American Chemical Society 127 (2): 506-507, 2005


Biosynthesis of carbapenem antibiotics: New carbapenam substrates for carbapenem synthase (CarC)
Sleeman MC, Smith P, Kellam B, Chhabra SR, Bycroft BW, Schofield CJ
ChemBiochem 5 (6): 879-882, 2004


Oxygen sensing by HIF hydroxylases
Schofield CJ, Ratcliffe PJ
Nat Rev Mol Cell Biol 5 (5): 343-354. 2004


Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase
Lloyd MD, Lipscomb SJ, Hewitson KS, Hensgens CMH, Baldwin JE, Schofield CJ
J Biol Chem 279 (15): 15420-15426, 2004


The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives
Tsang WY, Dhanda A, Schofield CJ, Frere JM, Galleni M, Page MI
Bioorg Med Chem Lett 14 (7): 1737-1739, 2004


Modulating the hypoxia-inducible factor signaling pathway: Applications from cardiovascular disease to cancer
Hewitson KS, McNeill LA, Schofield CJ
Curr Pharm Design 10 (8): 821-833, 2004


Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis
Sleeman MC, Schofield CJ
J Biol Chem 279 (8): 6730-6736, 2004


Role of Phytanoyl-CoA 2-hydroxylase in phytanic acid metabolism
Lloyd MD, Mukherji M, Kershaw NJ, Chien W, Wierzbicki AS, Schofield CJ
Adv Exp Med Biol 544: 303-304, 2003


Crystal structure and mechanistic implications of N-2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway
Caines MEC, Elkins JM, Hewitson KS, Schofield CJ
J Biol Chem 279 (7): 5685-5692, 2004


Kinetics and mechanisms of hydrolysis and aminolysis of thioxocephalosporins
Tsang WY, Dhanda A, Schofield CJ, Page MI
J Org Chem 69 (2): 339-344, 2004


Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis - Anthocyanidin synthase, flavonol synthase, and flavanone 3 beta-hydroxylase
Turnbull JJ, Nakajima J, Welford RWD, Yamazaki M, Saito K, Schofield CJ
J Biol Chem 279 (2): 1206-1216, 2004