Publications
Reviews
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Structural and mechanistic studies on anthocyanidin synthase catalysed oxidation of flavanone substrates: the effect of C-2 stereochemistry on product selectivity and mechanism
Richard W. D. Welford, Ian J. Clifton, Jonathan J. Turnbull, Stuart C. Wilson and Christopher J. Schofield
Org. Biomol. Chem. 3 , 3117 – 3126, 2005
Synthesis of delta-lactam (2-oxopiperazine) inhibitors of elastase
Seibel J, Macdonald SJ, Schofield CJ
Journal Of Chemical Research-S (12): 826-832, 2005
ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid
Arulanantham H, Kershaw NJ, Hewitson KS, Hughes CE, Thirkettle JE, Schofield CJ
J Biol Chem 281 (1): 279-287, 2006
Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease
McDonough MA, Kavanagh KL, Butler D, Searls T, Oppermann U, Schofield CJ
J Biol Chem 280 (49): 41101-41110, 2005
Signalling hypoxia by HIF hydroxylases
Schofield CJ, Ratcliffe PJ
Biochemical And Biophysical Research Communications 338 (1): 617-626, 2005
The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids
Banerji B, Garcia AC, McNeill LA, McDonough MA, Buck MRG, Hewitson KS, Oldham NJ, Schofield CJ
Chemical Communications (43): 5438-5440 2005
Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis
Sleeman MC, Sorensen JL, Batchelar ET, McDonough MA, Schofield CJ
J Biol Chem 280 (41): 34956-34965, 2005
Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans
Welford RWD, Kirkpatrick JM, McNeill LA, Puri M, Oldham NJ, Schofield CJ
FEBS Letters 579 (23): 5170-5174, 2005
A prodrug system for hydroxylamines based on esterase catalysis
Conejo-Garcia A, Schofield CJ
Bioorganic & Medicinal Chemistry Letters 15 (18): 4004-4009, 2005
The enzymology of clavam and carbapenem biosynthesis
Kershaw NJ, Caines MEC, Sleeman MC, Schofield CJ
Chemical Communications (34): 4251-4263 2005
Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands
Searls T, Butler D, Chien W, Mukherji M, Lloyd MD, Schofield CJ
Journal Of Lipid Research 46 (8): 1660-1667, 2005
Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling
Hewitson KS, Granatino N, Welford RWD, McDonough MA, Schofield CJ
Philosophical Transactions Of The Royal Society A - Mathematical Physical And Engineering Sciences 363 (1829): 807-828, 2005
Selective inhibition of factor inhibiting hypoxia-inducible factor
McDonough MA, McNeill LA, Tilliet M, Papamicael CA, Chen QY, Banerji B, Hewitson KS, Schofield CJ
Journal Of The American Chemical Society 127 (21): 7680-7681, 2005
Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine
Long AJ, Clifton IJ, Roach PL, Baldwin JE, Rutledge PJ, Schofield CJ
Biochemistry 44 (17): 6619-6628, 2005
OS-9: Another piece in the HIF complex story
Flashman E, McDonough MA, Schofield CJ
Molecular Cell 17 (4): 472-473, 2005
Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB) - implications for carbapenem biosynthesis
Sorensen JL, Sleeman MC, Schofield CJ
Chemical Communications (9): 1155-1157, 2005
X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster
Elkins JM, Kershaw NJ, Schofield CJ
Biochemical Journal 385: 565-573, 2005
Glyco - and peptidomimetics from three-component Joullie-Ugi coupling show selective antiviral activity
Chapman TM, Davies IG, Gu B, Block TM, Scopes DIC, Hay PA, Courtney SM, McNeill LA, Schofield CJ, Davis BG
Journal Of The American Chemical Society 127 (2): 506-507, 2005
A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases
McNeill LA, Bethge L, Hewitson KS, Schofield CJ
Analytical Biochemistry 336 (1): 125-131, 2005