Publications


Reviews
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4-Nitrobenzyl 5-oxo-2-(2-oxopiperidin-1-yl)-tetrahydrofuran-2-carboxylate
Shanley, S. J.; Schofield, C. J.; Coles, S. J.; Watkin, D. J.; Fischer, D. S. Acta Crystallographica Section E-Structure Reports Online 2007, 63 o1523-o1525.


Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH)
Schofield, C. J.; McDonough, M. A. Biochemical Society Transactions 2007, 35 870-875.


Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
Ng, S. S.; Kavanagh, K. L.; McDonough, M. A.; Butler, D.; Pilka, E. S.; Lienard, B. M. R.; Bray, J. E.; Savitsky, P.; Gileadi, O.; von Delft, F.; Rose, N. R.; Offer, J.; Scheinost, J. C.; Borowski, T.; Sundstrom, M.; Schofield, C. J.; Oppermann, U. Nature 2007, 448 (7149), 87-U8.


Mass spectrometric studies on an oxygen sensing prolyl hydroxylase
Mecinovic, J.; Lienard, B. M. R.; Chowdhury, R.; Schofield, C. J. Proceedings of the 5th Joint Meeting on Medicinal Chemistry 2007, 25-30.


Clavulanic acid dehydrogenase: Structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid
MacKenzie, A. K.; Kershaw, N. J.; Hernandez, H.; Robinson, C. V.; Schofield, C. J.; Andersson, I. Biochemistry 2007, 46 (6), 1523-1533.


Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins
Macheboeuf, P.; Fischer, D. S.; Brown, T.; Zervosen, A.; Luxen, A.; Joris, B.; Dessen, A.; Schofield, C. J. Nature Chemical Biology 2007, 3 (9), 565-569.


Combined mass spectrometry and dynamic chemistry approach to identify metalloenzyme inhibitors
Lienard, B. M. R.; Selevsek, N.; Oldham, N. J.; Schofield, C. J. Chemmedchem 2007, 2 (2), 175-+.


Inhibitors of the FEZ-1 metallo-beta-lactamase
Lienard, B. M. R.; Horsfall, L. E.; Galleni, M.; Frere, J. M.; Schofield, C. J. Bioorganic & Medicinal Chemistry Letters 2007, 17 (4), 964-968.

Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila
Horsfall, L. E.; Garau, G.; Lienard, B. M. R.; Dideberg, O.; Schofield, C. J.; Frere, J. A.; Galleni, M. Antimicrobial Agents and Chemotherapy 2007, 51 (6), 2136-2142.


Hypoxia-inducible factor prolyl-hydroxylase: Purification and assays of PHD2
Hewitson, K. S.; Schofield, C. J.; Ratcliffe, P. J. Oxygen Biology and Hypoxia 2007, 435 25-42.


Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
Hewitson, K. S.; Lienard, B. M. R.; McDonough, M. A.; Clifton, I. J.; Butler, D.; Soares, A. S.; Oldham, N. J.; McNeill, L. A.; Schofield, C. J. Journal of Biological Chemistry 2007, 282 (5), 3293-3301.


The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
Gerken, T.; Girard, C. A.; Tung, Y. C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. J. Science 2007, 318 1469-1472.


The most versatile of all reactive intermediates?
Flashman, E.; Schofield, C. J. Nature Chemical Biology 2007, 3 (2), 86-87.


Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay
Ehrismann, D.; Flashman, E.; Genn, D. N.; Mathioudakis, N.; Hewitson, K. S.; Ratcliffe, P. J.; Schofield, C. J. Biochemical Journal 2007, 401 227-234.


Asparaginyl hydroxylation of the notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor
Coleman, M. L.; McDonough, M. A.; Hewitson, K. S.; Coles, C.; Mecinovic, J.; Edelmann, M.; Cook, K. M.; Cockman, M. E.; Lancaster, D. E.; Kessler, B. M.; Oldham, N. J.; Ratcliffe, P. J.; Schofield, C. J. Journal of Biological Chemistry 2007, 282 (33), 24027-24038.


Mechanism for cyclization reaction by clavaminic acid synthase. Insights from modeling studies
Borowski, T.; de Marothy, S.; Broclawik, E.; Schofield, C. J.; Siegbahn, P. E. M. Biochemistry 2007, 46 (12), 3682-3691.