Publications


Reviews
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Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II)
Sekirnik R, Rose NR, Thalhammer A, Seden PT, Schofield CJ Chemical Communications 2009, 42, 6376-6378.  


Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2
Mecinovic J, Chowdhury R, Flashman E, Schofield CJ Analytical Biochemistry 2009, 393, 215-221.


2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2
Mecinovic J, Loenarz C, Chowdhury R, Schofield CJ Bioorganic & Medicinal Chemistry Letters 2009 19: 21 6192-6195.   


Synthesis and Evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors
Inglis SR, Zervosen A, Woon ECY, Gerards T, Teller N, Fischer DS, Luxen A, Schofield CJ Journal of Medicinal Chemistry 2009, 52, 6097-6106.   


Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function
Hardy AP, Prokes I, Kelly L, Campbell ID, Schofield CJ Journal of Molecular Biology 2009, 392, 994-1006.   


Epidithiodiketopiperazines Block the Interaction between Hypoxia-inducible Factor-1α (HIF-1α) and p300 by a zinc ejection mechanism
Cook KM, Hilton ST, Mecinovic J, Motherwell WB, Figg, WD, Schofield CJ J. Biol. Chem. 2009 284, 26831-26838


Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylase
Chowdhury R, McDonough MA, Mecinovic J, Loenarz C, Flashman E, Hewitson KS, Domene C, Schofield CJ Structure, 2009, 17, 981-989 


Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing
Webby CJ, Wolf A, Gromak N, Dreger M, Kramer H, Kessler B, Nielsen ML, Schmitz C, Butler DS, Yates, III JR, Delahunty CM, Hahn P, Lengeling A, Mann M, Proudfoot NJ, Schofield CJ, Böttger A Science 2009, 325, 90-93


A Mouse Model for the metabolic effects of the human fat mass and obesity associated FTO Gene
Church C, Lee S, Bagg EAL, McTaggart JS, Deacon R, gerken T, Lee A, Moir L, Mecinovic J, Quwailid, Schofield CJ, Ashcroft FM, Cox RD PLoS Genetics, 2009, 5, e1000599


Direct analysis of enzyme-catalyzed DNA demethylation
Karkhanina AA, Mecinovic J, Musheev MU, Krylova SM, Petrov AP, Hewitson KS, Flashman E, Schofield CJ, Krylov SN Analytical Chemistry   2009, 81, 5871-5875  .


Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2
Mecinovic J, Chowdhury R, Flashman E, Schofield CJ Anal Biochem  2009, 393, 215-221.


Oxygenase catalyzed 5-methylcytosine hydroxylation
Loenarz C, Schofield CJ Chemistry & Biology  2009, 16, 580-583.


Structural and mechanistic studies on N-2-(2-carboxyethyl)arginine synthase
Caines MEC, Sorensen JL, Schofield CJ Biochemical And Biophysical Research Communications   2009, 385, 512-517.


Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis
Ducho C Hamed RB, Batchelar ET, Sorensen JL, Odell B, Schofield CJ Organic & Biomolecular Chemistry   2009, 7, 2770-2779.  


Application of a proteolysis/mass Spectrometry method for investigating the effects of inhibitors on hydroxylase structure

Stubbs CJ, Loenarz C, Mecinovic J. Yeoh KK, Hindley N, Lienard BM, Sobott F, Schofield CJ, Flashman E Journal Of Medicinal Chemistry 2009. 52, 2799-2805.


Iron-Mediated Cleavage of C-C Bonds in vicinal tricarbonyl compounds in water
Mecinovic J, Hamed RB, Schofield CJ Angewandte Chemie-International Edition  2009, 48, 2796-2800.


Anatomy of a simple acyl intermediate in enzyme catalysis: Combined biophysical and modeling Studies on ornithine acetyl transferase
qbal A, Clifton IJ, Bagonis M, Kershaw NJ, Domene C, Claridge TDW, Wharton CW, Schofield CJ Journal of The American Chemical Society    2009, 131, 749-757.


Evidence for a Stereoelectronic Effect in Human Oxygen Sensing
Loenarz C, Mecinovic J, Chowdhury R, McNeill LA, Flashman E, Schofield CJ Angewandte Chemie-International Edition  2009, 48, 1784-1787.   


Triflic anhydride-mediated synthesis of oxazoles
Thalhammer A, Mecinovic J, Schofield CJ Tetrahedron Letters  2009, 50: 1045-1047.  


Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: Thne catalyzes the formation of (2S,5S)-trans-carboxymethylproline
Hamed RB, Batchelar ET, Mecinovic J Claridge TDW, Schofield CJ ChemBiochem   2009, 10, 246-250, 2009.