Publications

Reviews
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Structural studies on human 2-oxoglutarate oxygenases
McDonough MA, Loenarz C, Chowdhury R, Clifton IJ, Schofield CJ Current Opinion in Structural Biology, 2010, 20, 1-13.

Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6
Mantri, M; Krojer, T; Bagg, EA, Webby, CJ, Butler, Danica S, Kochan G, Kavanagh, KL, Oppermann, U, McDonough, MA, Schofield CJ Journal of Molecular Biology 2010, 401, 211-222.

Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1 alpha
Illingworth, CJR; Loenarz, C; Schofield, CJ, Domene, C Biochemistry 2010, 49, 6936-6944.

Structural basis for the interaction of Lactivicins with serine beta-lactamases
Brown, T; Charlier, P; Herman, R, Schofield CJ, Sauvage, E Journal of Medicinal Chemistry 2010, 53, 5890-5894.

Small-Molecule-Based Inhibition of Histone Demethylation in Cells Assessed by Quantitative Mass Spectrometry
Mackeen, MM; Kramer, HB; Chang, KH, Coleman ML, Hopkinson RJ, Schofield CJ, Kessler BM Journal of Proteome Research 2010, 9, 4082-4092.

A miniaturized screen for inhibitors of Jumonji histone demethylases
Sakurai, M; Rose, NR; Schultz, L, Quinn AM, Jadhav, A, Ng, SS, Oppermann U, Schofield CJ, Simeonov A Molecular Biosystems 2010, 6, 357-364.

Development of homogeneous luminescence assays for histone demethylase catalysis and binding
Kawamura, A; Tumber, A; Rose, NR, King ONF, Daniel M, Oppermann U, Heightman T, Schofield CJ Analytical Biochemistry 2010, 404, 86-93.

Fast and forceful refolding of stretched alpha-helical solenoid proteins
Kim M, Abdi K, Lee G, Rabbi M, Lee W, Yang M, Schofield CJ, Bennett V, Marszalek PE Biophysical Journal 2010, 98, 3086-3092.

Crystal structure of the PHF8 Jumonji domain, an N-epsilon-methyl lysine demethylase
Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CDO, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA FEBS Letters 2010, 584, 825-830.

2-Oxoglutarate oxygenases are inhibited by a range of transition metals
Sekirnik R, Rose NR, Mecinovic J, Schofield CJ Metallomics 2010, 2, 397-399.

Selective inhibitors of the JMJD2 histone demethylases: Combined nondenaturing mass spectrometric screening and crystallographic approaches
Rose NR, Woon ECY, Kingham GL, King ONF, Mecinovic J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, and Schofield CJ Journal of Medicinal Chemistry 2010, 53, 1810-1818.

Therapeutic manipulation of the HIF hydroxylases,
Nagel S, Talbot NP, Mecinovic J, Smith TG, Buchan AM, and Schofield CJ Antioxidants & Redox Signaling 2010, 12, 481-501.

Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid
Mackenzie AK, Valegard K, Iqbal A, Caines MEC, Kershaw NJ, Jensen SE, Schofield CJ, and Andersson I Journal of Molecular Biology 2010, 396, 332-344.

Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway
Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway

Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR Spectroscopy: Direct Observation of Formaldehyde
Hopkinson RJ, Hamed RB, Rose NR, Claridge TDW, and Schofield CJ ChemBioChem 2010, 11, 506-510.

Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles
Hamed RB, Mecinovic J, Ducho C, Claridge TDW, and Schofield CJ Chemical Communications 2010, 46, 1413-1415.

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents,
Flashman E, Davies SL, Yeoh KK, and Schofield CJ Biochemical Journal 2010, 427, 135-142.

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an N-epsilon-dimethyl lysine demethylase
Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CDO, Klose RJ, Ratcliffe PJ, Schofield CJ Human Molecular Genetics 2010, 19, 217-222.

Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions
Leung IKH, Flashman E, Yeoh KK, Schofield CJ, Claridge TDW Journal of Medicinal Chemistry 2010 53, 867-875.

Observations on the deprotection of pinanediol and pinacol boronate esters via fluorinated intermediates
Inglis SR, Woon ECY, Thompson AL, Schofield CJ Journal of Organic Chemistry 2010, 75, 468-471.