Publications


Reviews
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Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins
Clifton IJ, McDonough MA, Ehrismann D, Kershaw NJ, Granatino N, Schofield CJ
Journal Of Inorganic Biochemistry 100 (4): 644-669, 2006


Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling
Hewitson KS, Granatino N, Welford RWD, McDonough MA, Schofield CJ
Philosophical Transactions Of The Royal Society A-Mathematical Physical And Engineering Sciences 363 (1829): 807-828, 2005


Signalling hypoxia by HIF hydroxylases
Schofield CJ, Ratcliffe PJ
Biochemical And Biophysical Research Communications 338 (1): 617-626, 2005


Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases
Lancaster DE, McDonough MA, Schofield CJ
Biochemical Society Transactions 32: 943-945, 2004


The HIF pathway as a therapeutic target
Hewitson KS, Schofield CJ
Drug Discovery Today 9 (16): 704-711, 2004


Oxygen sensing by HIF hydroxylases
Schofield CJ, Ratcliffe PJ
Nat Rev Mol Cell Biol 5 (5): 343-354. 2004


Modulating the hypoxia-inducible factor signaling pathway: Applications from cardiovascular disease to cancer
Hewitson KS, McNeill LA, Schofield CJ
Curr Pharm Design 10 (8): 821-833, 2004


The chemical biology of branched-chain lipid metabolism
Mukherji M, Schofield CJ, Wierzbicki AS, Jansen GA, Wanders RJA, Lloyd MD
Prog Lipid Res 42 (5): 359-376, 2003


Chemistry of beta-Lactams
Westwood N J, Thirkettle J, Schofield C
Royal Society Of Chemistry, Specialist Periodical Reports, Amino Acids, Peptides And Proteins, 1997, 28, Chapter 5, 335-396.


The Mechanism of ACV Synthetase
Byford MF, Shiau C-Y, Baldwin JE, Schofield CJ
Chemical Reviews, 1997, 97, 2631-2649


Enzymes of penicillin biosynthesis
Schofield CJ Zhang Z-H, Barlow J N, Baldwin JE, Clifton I Byford M F, Roach PL
Current Structural Biology, 1997, 7, 857-864.


Chemistry of beta-lactams
Westwood NJ, Schofield CJ
Royal Society Of Chemistry, Specialist Periodical Reports, Amino Acids, Peptides And Proteins, 1995, 26, Chapter 6, 330-391.