|The Smallpox Protection Project|
Project Data Statement for the Smallpox Research Project
The Smallpox Research Project ("Project")
will attempt to analyze approximately 35 million molecules against a series
of protein targets related to smallpox. This Project is made possible
through the support of several Partner Organizations who have made various
contributions to this effort. The Partner Organizations include: Accelrys,
Evotec OAI, IBM, Oxford University, United Devices, and numerous scientific
researchers led by Dr. Grant McFadden and Dr. Stewart Shuman.
The hope is that a combination of the above efforts will help identify the most promising drug-like molecular candidates that could be effective in combating smallpox.
The resulting data ("Results Data"), produced as a result of the Project will consist of a list of "hits" and their relative score. When a molecule docks successfully with a protein, it registers as a hit and is scored or ranked for strength of interaction. By binding to the particular site the drug candidate would disable the virus. The ranked list of hits will be provided to the U.S. Department of Defense, who has contracted with United Devices for this Project through the U.S. Army Medical Research Institute of Infectious Diseases and potentially other allied governments (e.g., UK government, Canadian government) as directed by the US government, so that they also can take the "hits" and further process and develop them to help combat the use of smallpox as a bioterrorist threat or military weapon. It is essential that in blocking the action of smallpox the related human enzyme is not affected so the binding to that human target will also be tested.
Each Partner Organization has separately agreed
that it has no rights to the Results Data.
web site by Karl Harrison Department of Chemistry, University of Oxford