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APPLICATIONS OF ORGANIC SPECTROSCOPY
Dr. T.D.W. Claridge
Michaelmas Term – Third Year (4 lectures)
This course builds on the introductory material presented
in the second year, with emphasis on applications of NMR and
mass spectrometry to problem solving in organic chemistry,
including introductions to the most widely used modern experimental
techniques.
Lecture 1 NMR. This lecture will briefly recap on the
key features of 1H spectra of organic molecules and will then
cover further aspects of 13C NMR and introduce the concept
of two-dimensional NMR spectroscopy.
Lecture 2 NMR. This lecture will introduce two-dimensional
NMR techniques and will focus on their use in piecing together
organic structures.
Lecture 3 NMR. This lecture will introduce the nuclear
Overhauser effect with emphasis on its use in the elucidation
of molecular stereochemistry.
Lecture 4 Mass Spectrometry. This lecture will briefly
recap EI and CI, introduce electrospray ionisation, and then
discuss how the fragmentation of organic ions can be used
in organic structure elucidation.
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