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SUPPLEMENTARY SUBJECT
CHEMICAL PHARMACOLOGY
Organizer: Dr Grant Churchill
Department of Pharmacology
Email: grant.churchill@pharm.ox.ac.uk
This course will be run next year, but dates will obviously need adjustment.
Michaelmas and Hilary Terms 2009-10
16 lectures and 4 practicals
The Chemical Pharmacology course will provide students
with a flavour of how the interplay between chemistry
and pharmacology has contributed to the development
of drugs. Such drugs have played a major role in advancing
our basic understanding of basic biology and certain
ones have proven revolutionary in the treatments of
some diseases. The ultimate aim of this course is to
inspire chemistry students to not only think about how
chemistry can be applied to biological system, but to
do research in this area. Ideally, students from this
course will go on to synthesize compounds to treat diseases
that have, so far, proven intractable. (And very likely
get rich in doing so.) The initial lectures will provide
a background and overview of the relevant physiology
and pharmacology for those not well acquainted with
these topics. Subsequent lectures will concentrate on
specific physiological systems (e.g., communication
between nerves and muscle), what chemical targets these
systems provide (receptors or enzymes), and how a pharmacological
understanding of these targets has been exploited by
clever chemistry to develop useful drugs (e.g., antihistamines
that don’t cause drowsiness). To keep things lively,
certain controversial areas will also be touched on
such as chemical warfare agents, so-called smart drugs
that improve mental function, recreational drugs and
addiction and why society harbours such disdain for
the pharmaceutical industry.
Timetable
Lectures
Pharmacology Lecture Theatre
5-6 pm
2009 Michaelmas
(wk7), Wednesday, Nov 25
Introduction and Historical Perspective
Edward Gill
(wk7), Thursday, Nov 26
Drug targets and mechanisms of action
Grant Churchill
(wk8), Wednesday, Dec 2
Receptor Pharmacology
Grant Churchill
(wk8), Thursday, Dec 3
Drug Discovery and Development
Grant Churchill
2010 Hilary
5-6 pm
(wk1), Wednesday, Jan 20
Pharmacokinetics and Drug Metabolism
Grant Churchill
(wk1), Thursday, Jan 21
Computer-assisted Drug Design
Graham Richards
(wk2), Wednesday, Jan 27
Drugs affecting the heart
Derek Terrar
(wk2), Thursday, Jan 28
Neurotransmission
Nigel Emptage
(wk3), Wednesday, Feb 3
Anesthetics
Derek Terrar
(wk3), Thursday, Feb 4
Drugs affecting smooth muscle
Chris Garland
(wk4), Wednesday, Feb 10
Drugs used to treat mental illness
Trevor Sharp
(wk4), Thursday, Feb 11
Autonomic physiology and pharmacology
Tom Cunnane
(wk5), Wednesday, Feb 17
Recreational drug action and addiction
Trevor Sharp
(wk5), Thursday, Feb 18
Chemistry and Pharmacology of Cannabis
Les Iversen
(wk6), Wednesday, Feb 24
Drugs for controlling pain
Chas Bountra
(wk6), Thursday, Feb 25
Pharmacology of gastric acid secretion
Antony Galione
(wk7), Wednesday, March 3
Cancer and chemotherapy
Len Seymour
(wk7), Thursday, March 4
The workings of a Pharmaceutical Company
Edward Gill
Practicals
(wk7) Receptor activation and desensitization in smooth muscle
Mon 6.00 pm Dept of Pharmacology, Classroom
Grant Churchill
(wk7) Receptor activation and desensitization in smooth muscle
Tues 6.00 pm Dept of Pharmacology, Classroom
Grant Churchill
(wk7) Ferret Video (Matinee & Afternoon viewing)
Fri 1.00 pm Dept of Pharmacology, Lecture Theatre
Trevor Sharp
6.00 pm Dept of Pharmacology, Lecture Theatre
Sridhar Vasudevan
(wk8) Metabolism and excretion of aspirin
Mon 6.00 pm Dept of Pharmacology, Classroom
TBD
(wk8) Metabolism and excretion of aspirin
Tues 6.00 pm Dept of Pharmacology, Classroom
TBD
Final exam: Monday of 9th Week HT at 9.30 am (confirmed)
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