Department of Chemistry

Department of Chemistry University of Oxford

Flashman group work contributes to study published in Science revealing conserved oxygen-sensing mechanism in plants and humans

Flashman group work contributes to study published in Science revealing conserved oxygen-sensing mechanism in plants and humans

A collaborative project between the Ratcliffe group (NDM, Oxford), Licausi group (PlantLab, SSSUP, Pisa) and the Flashman group (Chemistry, Oxford) has revealed that an N-terminal cysteine dioxygenase in humans acts to control the stability of target proteins in an oxygen-sensitive manner. This mechanism is identical to oxygen-sensing cysteine dioxygenases in plants, which control plant responses to low oxygen (hypoxic) events such as flooding. The work broadens our understanding of cellular responses to hypoxia, a feature common to many disease states. Masson N et al (2019) Science 365:65-69. Picture by Mikel Lavilla and Beatrice Giuntoli. more........