On the Cover of RSC ChemComm
The paper describes the optimisation of fluorescent oligonucleotide substrates for the DNA repair protein, XPF-ERCC1. The protein, which cuts DNA to remove damaged nucleic acid bases, has been found to be upregulated in cancers resistant to vital DNA crosslinking chemotherapeutics, such as Cisplatin. The research aims to accelerate inhibitor discovery for XPF-ERCC1 which is currently an untapped drug target.
The work was carried out in Tom Brown's Chemistry lab, as well as Peter McHugh's lab at the Weatherall Institute of Molecular Medicine, and Neil McDonald's lab at the Francis Crick Institute. The collaboration was done through the Oxford-GSK-Crick Chemical Biology DTC.
The cover illustration was designed and created by Dr Karl Harrison.