Novel Gouverneur group Fluorination Catalyst now commercially available
A novel bis-urea organocatalyst for asymmetric fluorination with metal fluoride is now commercially available on Sigma Aldrich-Merck website.
Recently developed in the Gouverneur group (Science and J.A.C.S.), this novel class of phase-transfer catalysts allows for the first time the use of safe and low-cost alkali metal fluorides in asymmetric catalysis. By overcoming the intrinsic poor solubility of KF (and CsF) in common organic solvents, these catalysts form a soluble tridentate hydrogen-bonded complex with metal fluorides thus enabling highly efficient enantioselective transformations.