Department of Chemistry

Department of Chemistry University of Oxford

Cleaner methods for deuterium insertion will have applications across the life sciences

Cleaner methods for deuterium insertion will have applications across the life sciences

Deuterium is used in applications such as analytical chemistry and drug development. More recently deuterium has been used in an active pharmaceutical ingredient to prevent formation of a toxic metabolite. Research by the HydRegen team in the Vincent group has led to a new approach for deuterium insertion using the cheapest and cleanest deuterium source - D2O. New methods for deuterium insertion may help unlock the power of the kinetic isotope effect in drugs, providing more effective medicines with lower side effects. more........