Department of Chemistry

Department of Chemistry University of Oxford

Highlighted In Chemical Science

Highlighted In Chemical Science

Collaborative work between the Duarte and Ed Anderson groups, and led by DPhil student Alistair Sterling, has just been published in Chemical Science. This work explores the unusual reactivity of [1.1.1]propellane, a ubiquitous precursor to bicyclo[1.1.1]pentanes (BCPs), motifs of high value in pharmaceutical and materials research. This study challenges existing dogma (i.e. the so-called ‘strain-release’ driving force) and provides a unifying framework to rationalise the stability and broad reactivity of this molecule, inspiring new methods and applications yet to be invented. more........