Department of Chemistry

Department of Chemistry University of Oxford

Nature Chemical Biology article

Nature Chemical Biology article

Collaborative work between the groups of Emmanuel Levy and Sam Safran (Weizmann Institute), Lorenzo Rovigatti (Rome Sapienza), Emanuele Locatelli (University of Vienna) and Jonathan Doye has appeared in Nature Chemical Biology. The article introduces a synthetic system of interacting dimeric and tetrameric protein complexes that undergoes liquid-liquid phase separation in yeast cells. The phase diagram of this two-component system is mapped out both in experiment and using theory and simulations, allowing the effects of the interaction strength between the dimers and tetramers on the phase diagram to be explored. more........