Department of Chemistry

Department of Chemistry University of Oxford

Nature Paper

Nature Paper

Collaborative work from a number of Oxford- and RFI-based groups including Professors Ben Davis, Veronique Gouverneur, Richard Compton, Shabaz Mohammed, Andrew Baldwin and Akane Kawamura has appeared in Nature. This research article reports a new way to edit proteins with a catalytic process driven by blue light (450 nm). This benign chemistry enables the introduction of reactive and labelled side-chains, thereby expanding the range of further transformations possible on proteins. Specifically, in situ generation of boronic acid catechol ester derivatives generates RH2C· radicals that form the native (β-CH2-γ-CH2) linkage of natural residues and post-translational modifications, whereas in situ potentiation of pyridylsulfonyl derivatives by Fe(II) generates RF2C· radicals that form equivalent β-CH2-γ-CF2 linkages bearing difluoromethylene labels. Post-translational access to such reactions and chemical groups on proteins could be useful in revealing and creating protein function. The study is published in the journal Nature. more........