Biology at the molecular level; synthesis and modification of biomolecules; development of biomolecular machines; molecular basis of biological mechanism.
Mechanistic studies of metalloenzyme redox catalysis; small molecule activation at metal centres in enzymes; new energy storage and generation solutions.
New mechanisms; biocatalysts for fine chemical synthesis; applications of immobilised enzyme cascades as heterogeneous catalysts in industrial biotechnology for chemical synthesis; quantification of catalysis.
Medicinal chemistry/probe synthesis and analysis
Creation of hit-lead-probe-drug candidates; development of diagnostic methods; molecular imaging of disease; novel methods for the interrogation of diseased systems; molecular strategies in targeted delivery; De Novo synthetic biology, novel therapeutic strategies.
Energetics and rates of biological reactions and interactions; novel spectroscopic and spectrometric methodologies; novel spectroscopic and spectrometric methodologies; protein two-dimensional assembly, protein recognition interfaces (immune, aptamer, peptide), direct imaging of biomolecules, biomolecular self-assembly; protein folding and aggregation; mechanism of magnetoreception.
Bio-inspired devices; detectors and sensors for biomolecules; derived diagnostic configurations, synthetic cells and tissues, industrial biotechnology.
Researchers associated with this theme
Dirk Aarts, Fraser Armstrong, Ed Anderson, Harry Anderson, Andrew Baldwin, Hagan Bayley, Paul Beer, Justin Benesch, Alice Bowen, Tom Brown, Tim Claridge, Stuart Conway, Steve Davies, Ben Davis, Jason Davis, Darren Dixon, Jonathan Doye, Nicola Farrer, Stephen Faulkner, Emily Flashman, Peter Hore, Akane Kawamura, Philipp Kukura, James McCullagh, Shabaz Mohammed, Mark Moloney, William Myers, Stephan Rauschenbach, Jeremy Robertson, Carol Robinson, Angela Russell, Chris Schofield, Lorna Smith, Chris Timmel, Claire Vallance, Kylie Vincent, Charlotte Williams, Michael Willis, Luet Wong.