Department of Chemistry   University of Oxford

 

Introduction to mass spectrometry services

The CRL mass spectrometry facility exists to support research groups across all areas of chemistry providing staff and students, within the department, access to a broad range of mass spectrometry systems and expertise in organic, inorganic and biological mass spectrometry. Academic related staff at the facility are also engaged in research utilising the tools of mass spectrometry and separation science. Staff and students within the chemistry department can access to mass spectrometry via four different routes.

Open access mass spectrometry: A walk up MS system on the ground floor (Lab 20.062) is available for anyone in the department providing both positive and negative ion electrospray mass spectra for small molecules (100-2500 amu). No training is required but please contact a member of the MS staff before using the system for the first time.

Mass Spectrometry service: A high resolution and an accurate mass spectrometry service is run on approximately a 24hr turnaround basis. A sample can be submitted to this service by anyone in Chemistry. Please see the relevant tabs on this page.

Trained-user instrumentation: The facility has a number of instruments available for projects involving more extended use of mass spectrometer systems. GC/MS, LC/MS, UPLC/MS, MALDI can all be accessed after initial training has been completed. See the Trained user section for further information or contact a member of the Mass Spectrometry Facility staff.

Research instruments: The research facility also has a number of more advanced mass spectrometer systems including FT-ICR-MS, SYNAPT ion mobility MS and nanoLC-ESI-MS. For experiments involving these instruments collaboration with the expertise of the MS staff is recommended.

In addition to providing access to instrumentation, the MS facility staff are able to provide help and support with Mass Spectrometry related information and experiments including sample preparation and data analysis. Please ask the MS staff for any help you may require.

Protocol and Safety in the mass spectrometry labs

  1. No lab coats to be worn in any of the MS labs.
  2. Open access autosampler is in continuous operation: Care should be taken not to touch it when submitting samples.
  3. Sources are hot! (usually between 100 and 350oC). Take care when cleaning.
  4. Never remove or tamper with any part of the mass spectrometer system. If a instrument is not working please report to a member of the MS facility staff.
  5. Data – you are responsible for keeping it safe. For all instruments other than open access – make sure you remove it from the instrument computer hard drive within at least 1 week. You may keep it on MassStore

Please read safety information on the mass spectrometry website and all information provided at Mass Spectrometer terminals

 

 

 

 

 

 

 

 

 

 

 

 

 


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