Our research group is interested in synthesis, catalysis and mechanistic studies. We are developing new catalytic asymmetric carbon-carbon bond forming reactions to rapidly access complex molecules from simple starting materials, and then test these methods in the construction of important targets like natural products and clinically used drugs.
Asymmetric cross-coupling reactions
We have developed a series of metal catalysed asymmetric reactions that form carbon–carbon bonds using readily accessible conditions. We are particularly interested in developing new catalytic asymmetric variations of widely used cross-coupling reactions like Suzuki-Miyaura coupling to allow rapid access to complex molecules with high diastereo- and enantiomeric control. We also perform mechanistic studies to understand how these transformations work, including asymmetric induction, so that we can design new ligands and catalysts. We have applied these methods to the synthesis of clinically used drugs and natural products such as fulvestrant, tafluprost, niraparib and the taxol core.
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