An enantioselective Brønsted acid catalyzed Mannich reaction between acetophenone derived enamines and N-Boc imines has been developed. Simple diol (S)-H(8)-BINOL has been identified as the optimal catalyst, to afford versatile beta-amino aryl ketones in good yield and enantiomeric excess.
Keywords:
Amines
,Catalysis
,Crystallography, X-Ray
,Imines
,Ketones
,Models, Molecular
,Molecular Structure
,Stereoisomerism
