Synthesis and Reactivity of 18F-Labeled α,α-Difluoro-α-(aryloxy)acetic Acids.

Symplectic ID: 
671426
Source: 
Manual
This is the preferred source?: 
1
Last Synced with Symplectic: 
Friday, 31 July, 2026 - 21:25
DOI: 
10.1021/acs.orglett.6b03730
Publication Date: 
Wednesday, 1 February, 2017
First Page: 
568
Last Page: 
571
Authors: 
Khotavivattana, T
Calderwood, S
Verhoog, S
Pfeifer, L
Preshlock, S
Vasdev, N
Collier, TL
Gouverneur, V
Authors list has been truncated: 
0
Editors list has been truncated: 
Abstract: 
In this work, we describe the 18F-labeling of α,α-difluoro-α-(aryloxy)acetic acid derivatives and demonstrate that these building blocks are amenable to post-18F-fluorination functionalization. Protodecarboxylation offers a new entry to 18F-difluoromethoxyarene, and the value of this approach is further demonstrated with coupling processes leading to representative 18F-labeled TRPV1 inhibitors and TRPV1 antagonists.
ISSN: 
1523-7060
Journal Title: 
Organic letters
eISSN: 
1523-7052
Volume: 
19
Issue: 
3
ID at Source: 
38AFE4B8-E35B-4781-8AD8-EC6D040B1C5D
Publication Status: 
Published
Open access: 
Publication Date - Display month part?: 
Publication Date - Display day part?: 
SSO preference: 
chem0068