Hydroacylation catalysts have been previously reported [ Chaplin, A. B. J. Am. Chem. Soc. 2012, 134, 4885 ] that couple an alkene and a β-thioether aldehyde using cationic rhodium(I) catalysts with small-bite-angle diphosphine ligands. The higher catalytic activity was attributed to the facilitation of reductive elimination of the final product in the catalytic cycle, while external Lewis bases, including solvent (acetone and acetonitrile), were found to have a protective effect against catalyst deactivation. In this contribution, the relative energetics of these processes are examined computationally, and a unique role for the external Lewis base is discovered in which the base intercepts a critical intermediate in a pathway leading to catalyst deactivation and redirects the reaction to productive hydroacylation.
3402 Inorganic Chemistry
,3405 Organic Chemistry
,34 Chemical Sciences
