My research focuses on developing new approaches to visualise and understand biomolecular structures and dynamics that are difficult to capture using conventional structural methods. I integrate native mass spectrometry with cryogenic structural imaging, using native ion manipulation and electrospray ion beam deposition (ESIBD) to isolate defined molecular states and preserve them for high-resolution structural analysis.
A major focus of my current research is membrane proteins, whose functions are governed by dynamic conformational states, molecular interactions and flexible regulatory regions. By connecting state-resolved information from native mass spectrometry with cryo-EM, I aim to uncover structural and regulatory mechanisms that can be obscured by conformational heterogeneity or conventional sample-preparation workflows.
More broadly, I am interested in how biomolecular structure and function are maintained or altered across different physical environments. My long-term goal is to develop integrated molecular imaging and analytical technologies that bridge native mass spectrometry, cryogenic structural imaging and biomolecular interface engineering, enabling dynamic biomolecular systems to be interrogated from new physical and structural perspectives.
