Pentamethylphenyl (Ph*) and related derivatives as useful acyl protecting groups for organic synthesis: a preliminary study

Cheong CB, Frost J, Donohoe T

A study of acyl protecting groups derived from the Ph* motif is reported. While initial studies indicated that a variety of functional groups were not compatible with the Br2-mediated cleavage conditions required to release the Ph* group, strategies involving the use of different reagents or a modification of Ph* itself (Ph*OH) were investigated to solve this problem.

Keywords:

HFIP

,

oxidative cleavage

,

protecting group

,

deprotection

,

acylium ion