Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy

Vuorinen A, Wilkinson IVL, Chatzopoulou M, Edwards B, Squire SE, Fairclough RJ, Bazan NA, Milner JA, Conole D, Donald JR, Shah N, Willis NJ

et al

August 2021

Journal article

Journal:

European Journal of Medicinal Chemistry

Volume:

220

Elsevier

113431

No abstract available

Keywords:

32 Biomedical and Clinical Sciences

3404 Medicinal and Biomolecular Chemistry

34 Chemical Sciences

Biotechnology

Pediatric

Duchenne/ Becker Muscular Dystrophy

Muscular Dystrophy

Rare Diseases

5.1 Pharmaceuticals

Musculoskeletal

Dose-Response Relationship, Drug

Drug Discovery

Humans

Hydrazines

Molecular Structure

Muscular Dystrophy, Duchenne

Pyrimidines

RNA, Messenger

Structure-Activity Relationship

Utrophin

DOI