Symplectic ID:
2032976
Source:
Scopus
Last Synced with Symplectic:
Saturday, 30 May, 2026 - 06:51
DOI:
10.1021/acs.orglett.4c03186
Publication Date:
Friday, 4 October, 2024
First Page:
8377
Last Page:
8381
Editors list has been truncated:
Abstract:
Isoquinolines are ubiquitous arenes found in many biologically useful molecules. While direct substitution at the heterocyclic ring is uncommon, reductive functionalization to form tetrahydroisoquinolines (THIQs) is straightforward. Herein, we describe a facile method for producing C4-functionalized isoquinolines from a readily available parent THIQ. This high-temperature transformation utilizes pyridine-N-oxide as an oxidant generating only volatile side products and is functional-group-tolerant.
ISSN:
1523-7060
Journal Title:
Organic Letters
eISSN:
1523-7052
Volume:
26
Issue:
39
ID at Source:
2-s2.0-85205717271
Publication Status:
Published
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