C-2 fluorinated castanospermines as potent and specific α-glucosidase inhibitors: synthesis and structure–activity relationship study

Li Y-X, Zhang M, Shimadate Y, Kato A, Wang J-Z, Jia Y-M, Fleet GWJ, Yu C-Y

19 March 2025

Journal article

Journal:

Organic & Biomolecular Chemistry

Volume:

Issue:

Royal Society of Chemistry (RSC)

pp.

2854 - 2877

No abstract available

Keywords:

3404 Medicinal and Biomolecular Chemistry

34 Chemical Sciences

Glycoside Hydrolase Inhibitors

Structure-Activity Relationship

alpha-Glucosidases

Molecular Docking Simulation

Halogenation

Molecular Structure

Indolizidines

DOI