Transcription factor binding and high resolution crystallographic studies (1.3 Å) of Dickerson-Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.
Keywords:
Cytosine
,5-Methylcytosine
,Transcription Factors
,DNA
,DNA Methylation
,Nucleic Acid Conformation
,Protein Binding
,Oxidation-Reduction
,Models, Molecular
