The first total synthesis of pandamarilactone-1, an alkaloid of Pandanus amaryllifolius, is reported. The nine-step synthesis features furan oxidation with singlet oxygen and then spiro-N,O-acetalization and elimination to generate the natural product and further Pandanus alkaloids, pandamarilactonines A-D.
Keywords:
Alkaloids
,Lactones
,Molecular Structure
,Pandanaceae
,Pyrrolidines
,Stereoisomerism
