γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II) dependent oxygenase that catalyses an essential step during carnitine biosynthesis in animals. BBOX is inhibited by ejection of structural zinc by a set of selenium containing analogues. Previous structural analyses indicated that an undisrupted N-terminal zinc binding domain of BBOX is required for catalysis. Ebselen is a relatively potent BBOX inhibitor, an observation which may in part reflect its cardioprotective properties.
Keywords:
Humans
,Zinc
,Organoselenium Compounds
,Azoles
,Enzyme Inhibitors
,Protein Conformation
,Protein Binding
,Structure-Activity Relationship
,Oxidation-Reduction
,Catalysis
,Models, Molecular
,gamma-Butyrobetaine Dioxygenase
,Isoindoles
