Reduction of aryl azides by thiols: Implications for the use of photoaffinity reagents

Staros JV, Bayley H, Standring DN, Knowles JR

Aryl azides are rapidly reduced by dithiothreitol at room temperature to the corresponding aryl amines. Glutathione and 2-mercaptoethanol react much more slowly. The relevance of this reaction to experiments involving aryl azide photoaffinity reagents is discussed. © 1978.