Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride

Sap JBI, Wilson TC, Kee CW, Straathof NJW, Ende CWA, Mukherjee P, Zhang L, Genicot C, Gouverneur V
29 January 2019
Journal article
Journal:
Chemical Science
,
Royal Society of Chemistry (RSC)

Herein, we report the radiosynthesis of 18F-difluoromethylarenes via the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [18F]fluoride.

DOI
10.1039/c8sc05096a
ORA record