Publications

Prof Timothy Donohoe and GSK
Metal and Activating Group Free C-4 Alkylation of Isoquinolines via a Temporary Dearomatization Strategy
Organic Letters, Jan 2023, DOI 10.1021/acs.orglett.2c04149

Prof Chris Schofield and Evotec
Natural and Synthetic 2-Oxogluturate Derivatives are Substrates for Oncogenic Variants of Human Isocitrate Dehydrogenase 1 and 2
Journal of Biological Chemistry, Feb 2023, DOI 10.1016/j.jbc.2023.102873

Prof Carol Robinson and OMass
G protein-coupled receptor pharmacology - insights from mass spectrometry
Pharmacological Reviews, Mar 2023, DOI 10.1124/pharmrev.120.000237

Prof Fernanda Duarte and Pfizer
Visible Light Photoredox-Catalyzed Decarboxylative Alkylation of 3-Aryl-Oxetanes and Azetidines via Benzylic Tertiary Radicals and Implications of Benzylic Radical Stability
The Journal of Organic Chemistry, Mar 2023, 10.1021/acs.joc.3c00083

Prof Richard Compton and Syngenta
Kinetics of Lipophilic Pesticide Uptake by Living Maize
Agricultural Science & Technology, Apr 2023, DOI 10.1021/acsagscitech.3c00042

Prof Veronique Gouverneur and Takeda
Regiodivergent Nucleophilic Fluorination under Hydrogen Bonding Catalysis: A Computational and Experimental Study
Journal of the American Chemical Society, Apr 2023, DOI 10.1021/jacs.3c01303

Prof Tim Claridge and AstraZeneca
Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function
Chemical Science, Apr 2023, DOI 10.1039/D2SC05944D

Prof Darren Dixon and Janssen
Fully Automated Flow Protocol for C(sp3)–C(sp3) Bond Formation from Tertiary Amides and Alkyl Halides
Organic Letters, May 2023, DOI 10.1021/acs.orglett.3c01390

Prof Tim Claridge and Bruker
A general scheme for generating NMR supersequences combining high- and low-sensitivity experiments
Chemical Communications, May 2023, DOI 10.1039/D3CC01472J

Prof Chris Schofield and IBM
Accelerating drug target inhibitor discovery with a deep generative foundation model
Science Advances, Jun 2023, DOI 10.1126/sciadv.adg7865

Profs Timothy Donohoe and Fernanda Duarte with Syngenta
Redox Reorganization: Aluminium Promoted 1,5-Hydride Shifts Allow the Controlled Synthesis of Multisubstituted Cyclohexenes
Angewandte Chemie, Jun 2023, DOI 10.1002/anie.202307424

Prof Edman Tsang and Johnson Matthey
Design and development of heterogeneous catalysts for sustainable formic acid-mediated alkylation of aromatics
Cell Reports Physical Science, Jun 2023, DOI 10.1016/j.xcrp.2023.101416

Prof Timothy Donohoe and GSK
Synthesis of Cyclopropanes via Hydrogen-Borrowing Catalysis
Organic Letters, Jun 2023, DOI 10.1021/acs.orglett.3c01768

Prof Carol Robinson with Thermo Fisher and OMass
Infrared Multiphoton Dissociation Enables Top-Down Characterization of Membrane Protein Complexes and G Protein-Coupled Receptors
Angewandte Chemie, Jun 2023, DOI 10.1002/anie.202305694

Prof Veronique Gouverneur and FluoRok
Fluorochemicals from fluorspar via a phosphate-enabled mechanochemical process that bypasses HF
Science, July 2023, DOI 10.1126/science.adi1557

Prof Carol Robinson and OMass
The solute carrier SPNS2 recruits PI(4,5)P2 to synergistically regulate transport of sphingosine-1-phosphate
Molecular Cell, Aug 2023, DOI 10.1016/j.molcel.2023.06.033

Prof Shabaz Mohammed and Thermo Fisher
Characterization of an Omnitrap-Orbitrap Platform Equipped with Infrared Multiphoton Dissociation, Ultraviolet Photodissociation, and Electron Capture Dissociation for the Analysis of Peptides and Proteins
Analytical Chemistry, Aug 2023, DOI 10.1021/acs.analchem.3c01899

Prof Chris Schofield and GSK
Photoaffinity labelling displacement assay using multiple recombinant protein domains
Biochemical Journal, Aug 2023, DOI 10.1042/BCJ20230129

Prof Michael Willis with GSK and Evotec
Photocatalytic Carboxylate to Sulfinamide Switching Delivers a Divergent Synthesis of Sulfonamides and Sulfonimidamides
JACS, Sep 2023, DOI 10.1021/jacs.3c07974

Prof Chris Schofield and GSK
αβ,α′β′-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes
ChemComm, Oct 2023, DOI 10.1039/D3CC02932H

Profs Stuart Conway and Fernanda Duarte with GSK
Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation
ACS Chemical Biology, Oct 2023, DOI 10.1021/acschembio.3c00437

Prof Stuart Conway and GSK
Bromodomain Factor 5 as a Target for Antileishmanial Drug Discovery
ACS Infectious Diseases, Oct 2023, DOI 10.1021/acsinfecdis.3c00431

Prof Harry Anderson and IBM
On-surface synthesis of a doubly anti-aromatic carbon allotrope
Nature, Oct 2023, DOI 10.1038/s41586-023-06566-8

Prof Akane Kawamure and Novo Nordisk
Identification and engineering of potent cyclic peptides with selective or promiscuous binding through biochemical profiling and bioinformatic data analysis
RSC Chemical Biology, Nov 2023, DOI 10.1039/D3CB00168G

Prof Harry Anderson and IBM
Aromaticity Reversal Induced by Vibrations in Cyclo[16]carbon
JACS, Dec 2023, DOI 10.1021/jacs.3c10207

Prof Stuart Conway and GSK
Small Molecule Ligands of the BET-like Bromodomain, SmBRD3, Affect Schistosoma mansoni Survival, Oviposition, and Development
Journal of Medicinal Chemistry, Dec 2023, DOI 10.1021/acs.jmedchem.3c01321

Prof Jonathan Burton and Vertex
Total Synthesis and Structure Confirmation of (E) and (Z)-Ocellenyne
Organic Letters, Dec 2022, DOI 10.1021/acs.orglett.2c03524

Prof Timothy Donohoe and Vertex
Alcohols as Efficient Intermolecular Initiators for a Highly Stereoselective Polyene Cyclisation Cascade
Chemistry: A European Journal, Dec 2022, DOI 10.1002/chem.202203732

Prof Carol Robinson and OMass
Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor
Nature Chemistry, Nov 2022, DOI 10.1038/s41557-022-01041-9

Profs Carol Robinson, Shabaz Mohammed and Philipp Kukura with Genentech
Lipids mediate supramolecular outer membrane protein assembly in bacteria
Science Advances, Nov 2022, Vol 8, Issue 44, DOI 10.1126/sciadv.adc9566

Prof Stephen Fletcher and Vertex
Scale-Up of a Rh-Catalyzed Asymmetric sp³-sp² Suzuki-Miyaura- Type Reaction
Organic Process Research & Development, Nov 2022, 26, 11, 3153–3160

Prof Edward Anderson and Janssen
Rhodium-catalyzed [2 + 2 + 2] cyclotrimerizations of yndiamides with alkynes
Organic Letters, Oct 2022, 24, 41, 7522–7526

Profs Stephan Rauschenbach, Justin Benesch and Carol Robinson with Thermo Fisher Scientific
Mass-selective and ice-free cryo-EM protein sample preparation via native electrospray ion-beam deposition
PNAS Nexus, Aug 2022, Volume 1, Issue 4

Profs Stuart Conway and Fernanda Duarte with Evotec and Pfizer
Identification of Histone Peptide Binding Specificity and Small- Molecule Ligands for the TRIM33 alpha and TRIM33 beta Bromodomains
ACS Chemical Biology, Sep 2022, 10.1021/acschembio.2c00266

Prof Stephan Rauschenbach and Thermo Fisher Scientific
A Preparative Mass Spectrometer to Deposit Intact Large Native Protein Complexes
ACS Nano, Aug 2022, 16, 9, 14443–14455

Prof Dirk Aarts and Syngenta
Mixture design applied to the rheology of clay gel mixtures
Rheologica Acta, Aug 2022, Vol 61, pages 811–825

Profs Chris Schofield, Fraser Armstrong and James McCullagh with GSK
Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors
Nat Comms, Aug 2022, 13, Article number: 4785

Prof Timothy Donohoe and Vertex
Alcohols as Alkylating Agents in the Cation-Induced Formation of Nitrogen Heterocycles
Angewandte Chemie, June 2022, DOI 10.1002/anie.202206800

Prof Michael Willis, UCB and Janssen
Photocatalytic Late-Stage Functionalization of Sulfonamides via Sulfonyl Radical Intermediates
ACS Catalysis, May 2022, DOI 10.1021/acscatal.2c01442

Prof Tom Brown and GSK
Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides
RSC Chemical Biology, May 2022, DOI 10.1039/D2CB00100D

Prof Timothy Donohoe and AstraZeneca
Evolution of the Dearomative Functionalization of Activated Quinolines and Isoquinolines: Expansion of the Electrophile Scope
Angewandte Chemie, May 2022, DOI 10.1002/anie.202204682

Prof Jonathan Burton and Pfizer
Transition Metal-Free, Visible Light-Mediated Radical Cyclisation of Malonyl Radicals onto 5-Ring Heteroaromatics
Advanced Synthesis & Catalysis, May 2022, 364, 10, 1724-31

Profs Ben Davis, Shabaz Mohammed and Andrew Baldwin with Janssen
Reductive site-selective atypical C,Z-type/N2-C2 cleavage allows C-terminal protein amidation
Science Advances, Apr 2022, DOI 10.1126/sciadv.abl867

Prof Peter Edwards and Johnson Matthey
Atomic Structure and Valence State of Cobalt Nanocrystals on Carbon under Syngas Versus Hydrogen Reduction
J. Phys. Chem. C, Apr 2022, 126, 14, 6325–6333

Prof Veronique Gouverneur with Pfizer, UCB and Janssen
[18F]Difluorocarbene for positron emission tomography
Nature, Mar 2022, 606, 102–108

Profs Veronique Gouverneur and Tim Claridge with Novartis
Asymmetric Azidation under Hydrogen Bonding Phase-Transfer Catalysis: A Combined Experimental and Computational Study
J. Am. Chem. Soc. Mar 2022, 144, 10, 4572–4584

Prof Timothy Donohoe and AstraZeneca
Extension of hydrogen borrowing alkylation reactions for the total synthesis of (−)-γ-lycorane
Chemical Communications, Mar 2022, doi: 10.1039/D2CC01248K

Prof Tom Brown and Takeda
The role of chemistry in the success of oligonucleotides as therapeutics
Journal of Organic Chemistry, Feb 2022, 18, 197–199

Prof Michael Willis and Pfizer
Reductant-Free Cross-Electrophile Synthesis of Di(hetero)arylmethanes by Palladium-Catalyzed Desulfinative C−C Coupling
Angewandte Chemie, Feb 2022, e202116775

Prof Akane Kawamura and Novo Nordisk
An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor
Chemical Science, Feb 2022, 13, 3256-3262

Prof Tim Claridge and Bruker
Modular Pulse Program Generation for NMR Supersequences
Analytical Chemistry, Feb 2022, 94, 4, 2271–2278

Dr Fay Probert, Prof Tim Claridge and Novartis
Determination of CSF GFAP, CCN5, and vWF Levels Enhances the Diagnostic Accuracy of Clinically Defined MS From Non-MS Patients With CSF Oligoclonal Bands
Frontiers in Immunology, Feb 2022, doi: 10.3389/fimmu.2021.811351

Prof Stephen Fletcher and Vertex
Catalytic asymmetric hydrometallation of cyclobutenes with salicylaldehydes
Chemical Science, Jan 2022, 13, 236-240

Prof Michael Willis and Vertex
Diverse saturated heterocycles from a hydroacylation/conjugate addition cascade
Chemical Science, Jan 2022, 13, 1504-1511

Prof Fernanda Duarte, Syngenta and AstraZeneca
Electrophilic Activation of [1.1.1]Propellane for the Synthesis of Nitrogen-Substituted Bicyclo[1.1.1]pentanes
Angewandte Chemie, Jan 2022, 61, e202111291

Profs Jeff Penfold and Robert Thomas with Unilever
Self-assembly of Quillaja saponin mixtures with different conventional synthetic surfactants
Colloids and Surfaces A, Jan 2022, 633, 2, 127854

Prof Michael Willis, UCB and Janssen
Exploiting Configurational Lability in Aza-Sulfur Compounds for the Organocatalytic Enantioselective Synthesis of Sulfonimidamides
Angewandte Chemie, Dec 2021, 60, 49, 25680-25687

Prof Carol Robinson and OMass Therapeutics
Anionic Dendritic Polyglycerol for Protein Purification and Delipidation
Applied Polymer Materials, Nov 2021, 3, 11, 5903-5911

Prof Edward Anderson and Pfizer
Synthesis of α-Quaternary Bicyclo[1.1.1]pentanes through Synergistic Organophotoredox and Hydrogen Atom Transfer Catalysis
Organic Letters, Nov 2021, 23, 21, 8628-8633

Prof Michael Willis, GSK and Evotec
Sulfinates from Amines: A Radical Approach to Alkyl Sulfonyl Derivatives via Donor–Acceptor Activation of Pyridinium Salts
Organic Letters, Nov 2021, 23, 21, 8488-8493

Prof Tim Claridge and Bruker
Parallel NMR Supersequences: Ten Spectra in a Single Measurement
JACS Au, Nov 2021, 1, 11, 1892-1897

Prof Darren Dixon and AstraZeneca
Switchable, Reagent-Controlled Diastereodivergent Photocatalytic Carbocyclisation of Imine-Derived α-Amino Radicals
Angewandte Chemie, Nov 2021, 60, 45, 24116-24123

Profs Ben Davis, Véronique Gouverneur, Andrew Baldwin and Shabaz Mohammed with Janssen
Post-translational insertion of boron in proteins to probe and modulate function
Nature Chemical Biology, Nov 2021, 17, pages 1245–1261

Profs Jeff Penfold and Robert Thomas with Unilever
Self-assembly in saponin mixtures: Escin/tea, tea/glycyrrhizic acid, and escin/glycyrrhizic acid mixtures
Colloids and Surfaces A: Physicochemical and Engineering Aspects, Nov 2021, 629, 127420

Prof Paul Beer and Johnson Matthey
Halogen Bonding Heteroditopic Materials for Cooperative Sodium Iodide Binding and Extraction
Chemistry - A European Journal, Oct 2021, 27:59, 14600-14604

Prof Michael Willis and Pfizer
Base-Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions
Angewandte Chemie, Oct 2021, 60, 41, 22461-22468

Prof Edward Anderson and Novartis
Synthetic Methodology: Building Bridges
Nature Chemistry, Sep 2021, 13, pages 928–930

Prof Tim Donohoe and GSK
Development of an enolate alkynylation approach towards the synthesis of the taiwanschirin natural products
Chemical Science, Sep 2021

Profs Jeff Penfold and Robert Thomas with Unilever
Adsorption and self-assembly properties of the plant based biosurfactant, Glycyrrhizic acid
Journal of Colloid and Interface Science, Sep 2021, 598, 444-454

Prof Tim Claridge and Bruker
Multiplexing experiments in NMR and multi-nuclear MRI
Progress in Nuclear Magnetic Resonance Spectroscopy, Aug 2021, 124-145, 1-56

Prof Tim Claridge and Bruker
Increasing sensitivity and versatility in NMR supersequences with new HSQC-based modules
Journal of Magnetic Resonance, Aug 2021, 329, 107027

Prof Ed Anderson, Janssen and Pfizer
Twofold Radical-Based Synthesis of N,C-Difunctionalized Bicyclo[1.1.1]pentanes
J. Am. Chem. Soc, Aug 2021, 143, 26, 9729–9736

Prof Dermot O'Hare and SCG
Ni₂Mn-layered double oxide electrodes in organic electrolyte based supercapacitors
RSC Advances, Aug 2021, Issue 44

Prof Stuart Conway and GSK
Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi
ACS Infesctious Diseases, Aug 2021, 7, 8, 2238–2249

Prof Angela Russell and Summit
Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy
European Journal of Medicinal Chemistry, Aug 2021, 220, 113431

Prof Chris Schofield and GSK
One-Step Synthesis of Photoaffinity Probes for Live-Cell MS-Based Proteomics
Chemistry - A European Journal, Jul 2021, 27, 1–10

Prof Carol Robinson and OMass Therapeutics
Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters
EMBO Journal, Jul 2021, 40:14

Prof Véronique Gouverneur, Pfizer and Janssen
Late-stage difluoromethylation: concepts, developments and perspective
Chemical Society Reviews, Jun 2021, 50, 8214-8247

Prof Carol Robinson, UCB and OMass Therapeutics
NaViA: A Program for the Visual Analysis of Complex Mass Spectra
Bioinformatics, Jun 2021, 1-3

Prof Edman Tsang and Siemens
Rapid Interchangeable Hydrogen, Hydride, and Proton Species at the Interface of Transition Metal Atom on Oxide Surface
JACS, May 2021, 143, 24, 9105–9112

Prof Tim Claridge and Bruker
Parallel nuclear magnetic resonance spectroscopy
Nature Reviews Methods Primers, Apr 2021, 1:27

Prof Tim Donohoe and GSK
Hydrogen borrowing catalysis using 1° and 2° alcohols: Investigation and scope leading to α and β branched products
Tetrahedron, Apr 2021, 86, 132051

Prof Edman Tsang and SCG Chemicals
Rational Design of Synergistic Active Sites for Catalytic Ethene/2-Butene Cross-Metathesis in a Rhenium-Doped Y Zeolite Catalyst
ACS Catalysis, Mar 2021, 11, 6, 3530–3540

Prof Ed Anderson and Pfizer
Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes
Nature Communications, Mar 2021, 12, 1644

Prof Carol Robinson and Novo Nordisk
The Effects of Sodium Ions on Ligand Binding and Conformational States of G Protein-Coupled Receptors—Insights from Mass Spectrometry
J. Am. Chem. Soc. Mar 2021, 143, 11, 4085–4089

Prof Tim Donohoe and AstraZeneca
Hydrogen-Borrowing Alkylation of 1,2-Amino Alcohols in the Synthesis of Enantioenriched gamma-Aminobutyric Acids
Angewandte Chemie, Feb 2021, 60, 13, 6981-6985

Prof Dermot O'Hare and SCG
Synthesis of ultra-high molecular weight poly(ethylene)-co-(1-hexene) copolymers through high-throughput catalyst screening
RSC Advances, Feb 2021, 11, 5644-5650

Prof Jeremy Robertson and Vertex
Synthesis of legonmycins A and B, C(7a)-hydroxylated bacterial pyrrolizidines
Beilstein Journal of Organic Chemistry, Feb 2021, 17, 334–342

Prof Stuart Conway and AstraZeneca
Development of isotope-enriched phosphatidylinositol-4-and 5-phosphate cellular mass spectrometry probes
Chemical Science, Feb 2021, 12, 2549-2557

Prof Tim Donohoe and AstraZeneca
Single point activation of pyridines enables reductive hydroxymethylation
Chemical Science, Jan 2021, 12, 742-746

Prof Michael Willis and UCB
Primary Sulfonamide Synthesis Using the Sulfinylamine Reagent N-Sulfinyl-O-(tert-butyl)hydroxylamine, t-BuONSO
Organic Letters, Nov 2020, 22, 24, p9495–9499

Dr Hamish Yeung and Johnson Matthey
Use of open source monitoring hardware to improve the production of MOFs: using STA-16(Ni) as a case study
Scientific Reports, Oct 2020, 10, 17355

Prof Ed Anderson and Syngenta
Synthesis and Structure-Activity Relationship of Dehydrodieugenol B Neolignans against Trypanosoma cruzi
ACS Infectious Diseases, Oct 2020, 6, 11, p2872–2878

Profs Michael Willis and Fernanda Duatre with UCB
Harnessing Sulfinyl Nitrenes: A Unified One-Pot Synthesis of Sulfoximines and Sulfonimidamides
J. Am. Chem. Soc. Sep 2020, 142, 36, p15445–15453

Prof Tim Donohoe and Eli Lilly
Rhodium catalysed C-3/5 methylation of pyridines using temporary dearomatisation
Chemical Science, Aug 2020,11, p8595-8599

Prof Veronique Gouverneur, GSK and Pfizer
Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C-O Cross-Coupling
Organic Letters, Aug 2020, 22, 16, p6573–6577

Prof Veronique Gouverneur and Janssen
Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of gamma-Fluoroamines
J. Am. Chem. Soc. Jul 2020, 142, 33, p14045–14051

Prof Harry Anderson and IBM
Synthesis of Cyclo[18]carbon via Debromination of C18Br6
J. Am. Chem. Soc. Jul 2020, 142, 30, p12921-12924

Prof Dermot O'Hare and SCG
Metallocene Polyethylene Wax Synthesis
Macromolecules, Jul 2020, 53, 14, p5847-5856

Prof Ed Anderson, Pfizer and Syngenta
Synthesis of All‐Carbon Disubstituted Bicyclo[1.1.1]pentanes by Iron‐Catalyzed Kumada Cross‐Coupling
Angewandte Chemie, Jul 2020, 59, 29, p11866-11870

Profs Veronique Gouverneur and Michael Willis with Janssen
Hydrosulfonylation of Alkenes with Sulfonyl Chlorides under Visible Light Activation
Angewandte Chemie, Jul 2020, 59, 28, p11620-11626

Profs Jeff Penfold and Robert Thomas with Unilever
Mixing Natural and Synthetic Surfactants: Co-Adsorption of Triterpenoid Saponins and Sodium Dodecyl Sulfate at the Air–Water Interface
Langmuir, Jun 2020, 36, 21, p5997–6006

Prof Paul Beer and Johnson Matthey
N‐Functionalised Imidazoles as Stabilisers for Metal Nanoparticles in Catalysis and Anion Binding
Chemistry Open, June 2020, 9, 6, p683-690

Prof Charlotte Williams and Johnson Matthey
Cu/M:ZnO (M = Mg, Al, Cu) colloidal nanocatalysts for the solution hydrogenation of carbon dioxide to methanol
Journal of Materials Chemistry A, May 2020, 8, p11282-11291

Prof Veronique Gouverneur, Pfizer, UCB and Janssen
Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery
J. Am. Chem. Soc, May 2020, 142, 20, p9181–9187

Prof Edman Tsang and Siemens
Removal of Hydrogen Poisoning by Electrostatically Polar MgO Support for Low-Pressure NH3 Synthesis at a High Rate over the Ru Catalyst
ACS Catalysis, May 2020, 10, 10, p5614–5622

Prof Jonathan Burton and Pfizer
Organophotochemical SNAr Reactions of Mildly Electron‐Poor Fluoroarenes
European Journal of Organic Chemistry, May 2020, 18, p2766-2770

Profs Fernanda Duarte and Ed Anderson with Janssen
Rationalizing the diverse reactivity of [1.1.1]propellane through σ–π-delocalization
Chemical Science, April 2020, 11, p4895-4903

Prof Darren Dixon and Bayer
Catalytic Enantioselective Direct Aldol Addition of Aryl Ketones to alpha-Fluorinated Ketones
Angewandte Chemie, Mar 2020, 59, 13, p5359-5364

Prof Ed Anderson and UCB
A Modular, Enantioselective Synthesis of Resolvins D3, E1, and Hybrids
Organic Letters, Feb 2020, 22, 4, p1510-1515

Prof Angela Russell and Summit Therapeutics, SHB Enterprises and Evotec
Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid
Angewandte Chemie, Feb 2020, 59, 6, p2420-2428

Profs Veronique Gouverneur and Michael Willis with Janssen
Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes
J. Am. Chem. Soc. Jan 2020, 142, 2, p720–725

Prof Angela Russell and Summit Therapeutics
Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model
Tetrahedron, Jan 2020, 76, 2, 130819

Prof Angela Russell and Summit Therapeutics
Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase
Bioorganic Chemistry, Jan 2020, 94, 103395

Prof Michael Willis and Pfizer
Cyclic Alkenylsulfonyl Fluorides: Palladium-Catalyzed Synthesis and Functionalization of Compact Multifunctional Reagents
Angewandte Chemie, Dec 2019, 58, 52, 18859-18863

Prof Tim Claridge and Bruker
Triplet NOAH supersequences optimised for small molecule structure characterisation
MRC, Nov 2019, 57, 11, 946-952

Prof Timothy Donohoe and Eli Lilly
Transition-Metal-Free Reductive Hydroxymethylation of Isoquinolines
Angewandte Chemie, Oct 2019, 58, 44, 15697-15701

Prof Veronique Gouverneur and Janssen
Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid
Angewandte Chemie, Jun 2019, 58, 26, p8829-8833

Prof Timothy Donohoe and GSK
Rhodium-catalysed vinyl 1,4-conjugate addition coupled with Sharpless asymmetric dihydroxylation in the synthesis of the CDE ring fragment of pectenotoxin-4
Chemical Science, May 2019, 10, 6336-6340

Prof Ed Anderson and Janssen
A General Copper-Catalyzed Synthesis of Ynamides from 1,2-Dichloroenamides
Organic Letters, Apr 2019, 21, 8, 2918-2922

Prof Ed Anderson and Pfizer
Synthesis of Enantioenriched α-Chiral Bicyclo[1.1.1]pentanes
Organic letters, Apr 2019, 21, 7, 2408–2411

Prof Darren Dixon and Bayer
One-Pot Catalytic Enantioselective Synthesis of 2-Pyrazolines
Angewandte Chemie, Feb 2019, 58, 8, 2469-2473

Prof Justin Benesch and Waters Corp
Probing the Dissociation of Protein Complexes by Means of Gas-Phase H/D Exchange Mass Spectrometry
Journal of the American Society for Mass Spectrometry, Nov 2018, 30, 45–57

Prof Veronique Gouverneur, Pfizer and UCB
Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride
Chemical Science, 2019, 10, 3237-3241

Prof Stephen Fletcher and Vertex
Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
Nature Communications, Jan 2019, 10, 21

Prof Tim Donohoe and Eli Lilly
The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation
Nature Chemistry, Dec 2018, 11, 242–247. DOI 10.1038/s41557-018-0178-5

Prof Darren Dixon and Bayer
One‐Pot Catalytic Enantioselective Synthesis of 2‐Pyrazolines
Angewandte Chemie, Dec 2018. DOI 10.1002/anie.201811471

Prof Akane Kawamura and Promega Corporation
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors
Angewandte Chemie, Nov 2018. 10.1002/anie.201810179

Prof Michael Willis and Pfizer
Heterocyclic Allylsulfones as Latent Heteroaryl Nucleophiles in Palladium-Catalyzed Cross-Coupling Reactions
Journal of the American Chemical Society, Nov 2018, 140 (46), pp 15916–15923

Profs Carol Robinson and Luet Wong, and OMass
An electron transfer path connects subunits of a mycobacterial respiratory supercomplex
Science, Nov 2018, 362, 6418. DOI 10.1126/science.aat8923

Prof Michael Willis and Evotec
Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes
Organic & Biomolecular Chemistry, Oct 2018, 16, 7797-7800

Prof Darren Dixon and Astex
Photocatalytic Three-Component Umpolung Synthesis of 1,3-Diamines
Organic Letters, Oct 2018, 20, 21, 6794–6798

Prof Tom Brown and AstraZeneca
Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue
Scientific Reports, Sep 2018, DOI 10.1038/s41598-018-31897-2

Prof Angela Russell and AstraZeneca
Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors
ACS Chemical Biology, Sep 2018, DOI 10.1021/acschembio.8b00665

Prof Michael Willis and GlaxoSmithKline
Copper-Catalyzed Synthesis of Activated Sulfonate Esters from Boronic Acids, DABSO, and Pentafluorophenol
Organic Letters, Aug 2018, 20 (17), pp 5493–5496

Prof Carol Robinson and OMass
PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling
Nature, Jul 2018, 559, 423–427

Prof Harry Anderson and IBM
Polyyne formation via skeletal rearrangement induced by atomic manipulation
Nature Chemistry, Jul 2018, 10, 853–858

Prof Stuart Conway and GlaxoSmithKline
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
Bioorganic & Medicinal Chemistry, Jul 2018, 26 (11), 2937-2957

Profs Hagan Bayley, Justin Benesch and Carol Robinson, and OMass
Lipid binding attenuates channel closure of the outer membrane protein OmpF
PNAS, Jun 2018, DOI 10.1073/pnas.1721152115

Prof Tim Claridge and Bruker
Molecular structure from a single NMR supersequence
Chemical Communications, May 2018, 54, 7139-7142

Profs Justin Benesch and Carol Robinson, and Waters Corporation
Identifying key membrane protein lipid interactions using mass spectrometry
Nature Protocols, Apr 2018, 13, 1106–1120

Prof Edward Anderson and Pfizer
Synthesis and applications of highly functionalized 1-halo-3-substituted bicyclo[1.1.1]pentanes
Chemical Science, May 2018, DOI 10.1039/C8SC01355A

Prof Veronique Gouverneur and Lilly
Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
Science, May 2018, 360, 638-642

Profs Andrew Weller and Michael Willis with AstraZeneca
Rh(DPEPhos)-Catalyzed Alkyne Hydroxylation Using -Carbonyl-Substituted Aldehydes: Mechanistic Insight Leads to Low Catalyst Loadings that Enables Selective Catalysis on Gram-Scale
J. Am. Chem. Soc, May 2018, DOI: 10.1021/jacs.8b04086

Prof Tom Brown and Metabion
Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures
Chemical Communications, Apr 2018, DOI 10.1039/C8CC00738A

Profs Chris Schofield, Shabaz Mohammed and Dr Emily Flashman, with Novartis and AbbVie
YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase
Extremophiles, Mar 2018, 22, p553–562. DOI 10.1007/s00792-018-1016-9

Prof Tom Brown and AstraZeneca
Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue
Chemical Science, Mar 2018, 9, 3494-3502. DOI 10.1039/C7SC05448C

Prof Chris Schofield and GSK
Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces
ChemMedChem, Mar 2018, 13, 1051-1057

Prof Darren Dixon and UCB
Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macro domain 2
Bioorganic & Medicinal Chemistry, Mar 2018, DOI: 10.1016/j.bmc.2018.03.020

Prof Justin Benesch and Waters Corporation
Mass spectrometry beyond the native state
Current Opinion in Chemical Biology, Feb 2018, 42, 130-137

Profs Darren Dixon, Chris Schofield, Martin Smith, Mike Willis and UCB
Direct sulfonylation of anilines mediated by visible light
Chemical Science, 2018, 9, 629-633

Prof Dermot O'Hare and SCG
Slurry-Phase Ethylene Polymerisation Using Pentafluorophenyl- and Pentafluorophenoxy- Modified Solid Polymethulaluminoxanes
Organometallics, Jan 2018, 37, 156-164

Prof Fraser Armstrong and SCG
A hydrogen fuel cell for rapid, enzyme-catalysed organic synthesis with continuous monitoring
Chemical Communications, Jan 2018, 54, 972-975

Profs Steve Fletcher and Rob Paton with Vertex
Formation of quaternary centres by copper catalysed asymmetric conjugate addition to beta-substituted cyclopentneones with the aid of a quantitative structure-selectivity relationship
Chemical Science, Feb 2018, 9, 2628-2632

Prof Michael Willis and GSK
Oxidative Beta-Sulfonylation of Cyclic Amines
Chemical Science, Jan 2018, 9, 2295-2300

Prof Dermot O'Hare and SCG
Zirconium arena triple-decker sandwich complexes: synthesis, electronic structure and bonding
Chem. Commun. 2017, 53, 12048-12051

Profs Darren Dixon, Rob Paton, Christopher Schofield, Martin Smith, Mike Willis and UCB
A C-H Cyanation of 6-Ring N-Containing Heteroaromatics
Chem. Eur. J. 2017, 23, 14733-14737

Prof Andrew Baldwin and ZoBio
Automatic Assignment of Methyl-NMR Spectra of Supramolecular Machines Using Graph Theory
J. Am. Chem. Soc. 2017, 139, 9523-9533

Prof Mike Willis and UCB
One-pot, Three-Component Sulfonimidamide Synthesis exploiting the Sulfinylamine Reagent N-Sulfinyltritylamine, TrNSO
Angew. Chem. Int. Ed. 2017, 56, 14937-14941

Prof Carol Robinson and OMass
Native Desorption Electrospray Ionisation Liberates Soluble and Membrane Protein Complexes from Surfaces
Angew. Chem. Int. Ed.  2017, 56, 14463-14468

Prof Veronique Gouverneur and UCB
Derisking the Cu-Mediated F-18-Fluorination of Heterocyclic Positron Emission Tomography
J. Am. Chem. Soc. 2017, 139 (24), 8267-8276

Prof Tim Claridge and Bruker
NOAH - NMR Supersequences for Small Molecule Analysis and Structure Elucidation
Angew. Chem. Int. Ed.  2017, 129, 11941-11945

Prof Edman Tsang and SINOPEC
Decarboxylation of Lactones over Zn/ZSM-5: Elucidations of the Structure of the Active Site and Molecular Interactions
Angew. Chem. Int. Ed. 2017, 129, 10851-10856

Prof Tom Brown and AstraZeneca
Towards Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET
J. Am. Chem. Soc. 2017, 139 (27), 9271-9280

Prof Philip Mountford and SCG
Reactions of Titanium Imides and Hydrazides with Boranes
Organometallics 2017, 36, 3329-3342

Prof Veronique Gouverneur and UCB
Bridging the gaps in 18F PET tracer development
Nat. Chem. 2017, 9 (1), 1-3

Profs Luet Wong and Jeremy Robertson and Syngenta
Hydroxylation of anilines by engineered cytochrome P450(BM3)
Org. Biomol. Chem. 2017, 15, 8780-8787

Prof Tim Donohoe and GSK
Hydrogen Borrowing Catalysis with Secondary Alcohols: A New Route for the Generation of beta-Branched Carbonyl Compounds
J. Am. Chem. Soc. 2017, 139 (7), 2577-2580

Prof Mike Willis and Pfizer
Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalysed cross-coupling reactions with aryl halides
Chem. Sci. 2017, 8, 4437-4442

Prof Philip Mountford and Arlanxeo
Monometallic and Bimetallic Titanium K1-Amidinate Complexes as Olefin Polymerisation Catalysts
Organometallics, 2017, 36 (11), 2167-2181

Prof Carol Robinson and Spiber Technologies
Efficient protein production inspired by how spiders make silk
Nat. Commun. 2017, 8, 15504

Profs Dermot O'Hare and Edman Tsang and SCG
Hydrodeoxygenation of water-insoluble bio-oil to alkanes using highly dispersed Pd-Mo catalyst
Nature Comm. 2017, 8, 1591

Prof Veronique Gouverneur and Eli Lilly
The dual role of thiourea in the thiotrifluoromethylation of alkenes
Chem. Sci. 2017, 8, 1195-1199

Prof Ed Anderson and Pfizer
Mechanistic Study of Arylsilane Oxidation through 19-F NMR Spectroscopy
J. Am. Chem. Soc. 2017, 139 (17), 6138-6145

Prof Roel Dullens, Prof Dirk Aarts and Unilever
The effect of colloidal aggregates on fat crystal networks
Food Funct. 2017, 8 (1), 352-359

Prof Tim Donohoe and AstraZeneca
Catalytic Enolate Arylation with 3-Bromoindoles Allows the Formation of beta-Carbolines
J. Org. Chem. 2017, 82 (8), 4435-4443

Prof Philip Mountford and SCG
New Titanium Borylimido Compounds: Synthesis, Structure and Bonding
Inorg. Chem. 2017, 56, 10794-10814

Prof Veronique Gouverneur and Advion Biosystems
Synthesis and Reactivity of F-18-Labeled alpha,alpha-Difluoro-alpha(aryloxy(acetic Acids
Org. Lett. 2017, 19 (3), 568-571

Prof Darren Dixon and UCB
Discovery of a PCAF Bromodomain Chemical Probe
Angew. Chem. Int. Ed. 2017, 56, 827

Prof Mike Willis and Pfizer
One-pot palladium-catalysed synthesis of sulfonyl fluorides from aryl bromides
Chem. Sci. 2017, 8, 1233-1237