Publications

Prof Edman Tsang and SCG Chemicals
Rational Design of Synergistic Active Sites for Catalytic Ethene/2-Butene Cross-Metathesis in a Rhenium-Doped Y Zeolite Catalyst
ACS Catalysis, Mar 2021, 11, 6, 3530–3540

Prof Ed Anderson and Pfizer
Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes
Nature Communications, Mar 2021, 12, 1644

Prof Carol Robinson and Novo Nordisk
The Effects of Sodium Ions on Ligand Binding and Conformational States of G Protein-Coupled Receptors—Insights from Mass Spectrometry
J. Am. Chem. Soc. Mar 2021, 143, 11, 4085–4089

Prof Tim Donohoe and AstraZeneca
Hydrogen-Borrowing Alkylation of 1,2-Amino Alcohols in the Synthesis of Enantioenriched gamma-Aminobutyric Acids
Angewandte Chemie, Feb 2021, 60, 13, 6981-6985

Prof Dermot O'Hare and SCG
Synthesis of ultra-high molecular weight poly(ethylene)-co-(1-hexene) copolymers through high-throughput catalyst screening
RSC Advances, Feb 2021, 11, 5644-5650

Prof Jeremy Robertson and Vertex
Synthesis of legonmycins A and B, C(7a)-hydroxylated bacterial pyrrolizidines
Beilstein Journal of Organic Chemistry, Feb 2021, 17, 334–342

Prof Stuart Conway and AstraZeneca
Development of isotope-enriched phosphatidylinositol-4-and 5-phosphate cellular mass spectrometry probes
Chemical Science, Feb 2021, 12, 2549-2557

Prof Tim Donohoe and AstraZeneca
Single point activation of pyridines enables reductive hydroxymethylation
Chemical Science, Jan 2021, 12, 742-746

Prof Michael Willis and UCB
Primary Sulfonamide Synthesis Using the Sulfinylamine Reagent N-Sulfinyl-O-(tert-butyl)hydroxylamine, t-BuONSO
Organic Letters, Nov 2020, 22, 24, p9495–9499

Dr Hamish Yeung and Johnson Matthey
Use of open source monitoring hardware to improve the production of MOFs: using STA-16(Ni) as a case study
Scientific Reports, Oct 2020, 10, 17355

Prof Ed Anderson and Syngenta
Synthesis and Structure-Activity Relationship of Dehydrodieugenol B Neolignans against Trypanosoma cruzi
ACS Infectious Diseases, Oct 2020, 6, 11, p2872–2878

Profs Michael Willis and Fernanda Duatre, and UCB Biopharma
Harnessing Sulfinyl Nitrenes: A Unified One-Pot Synthesis of Sulfoximines and Sulfonimidamides
J. Am. Chem. Soc. Sep 2020, 142, 36, p15445–15453

Prof Tim Donohoe and Eli Lilly
Rhodium catalysed C-3/5 methylation of pyridines using temporary dearomatisation
Chemical Science, Aug 2020,11, p8595-8599

Prof Veronique Gouverneur, GSK and Pfizer
Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C-O Cross-Coupling
Organic Letters, Aug 2020, 22, 16, p6573–6577

Prof Veronique Gouverneur and Janssen
Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of gamma-Fluoroamines
J. Am. Chem. Soc. Jul 2020, 142, 33, p14045–14051

Prof Harry Anderson and IBM
Synthesis of Cyclo[18]carbon via Debromination of C18Br6
J. Am. Chem. Soc. Jul 2020, 142, 30, p12921-12924

Prof Dermot O'Hare and SCG
Metallocene Polyethylene Wax Synthesis
Macromolecules, Jul 2020, 53, 14, p5847-5856

Prof Ed Anderson, Pfizer and Syngenta
Synthesis of All‐Carbon Disubstituted Bicyclo[1.1.1]pentanes by Iron‐Catalyzed Kumada Cross‐Coupling
Angewandte Chemie, Jul 2020, 59, 29, p11866-11870

Profs Veronique Gouverneur and Michael Willis, and Janssen
Hydrosulfonylation of Alkenes with Sulfonyl Chlorides under Visible Light Activation
Angewandte Chemie, Jul 2020, 59, 28, p11620-11626

Drs Jeffrey Penfold and R.K. Thomas, and Unilever
Mixing Natural and Synthetic Surfactants: Co-Adsorption of Triterpenoid Saponins and Sodium Dodecyl Sulfate at the Air–Water Interface
Langmuir, Jun 2020, 36, 21, p5997–6006

Prof Paul Beer and Johnson Matthey
N‐Functionalised Imidazoles as Stabilisers for Metal Nanoparticles in Catalysis and Anion Binding
Chemistry Open, June 2020, 9, 6, p683-690

Prof Charlotte Williams and Johnson Matthey
Cu/M:ZnO (M = Mg, Al, Cu) colloidal nanocatalysts for the solution hydrogenation of carbon dioxide to methanol
Journal of Materials Chemistry A, May 2020, 8, p11282-11291

Prof Veronique Gouverneur, Pfizer, UCB and Janssen
Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery
J. Am. Chem. Soc, May 2020, 142, 20, p9181–9187

Prof Edman Tsang and Siemens
Removal of Hydrogen Poisoning by Electrostatically Polar MgO Support for Low-Pressure NH3 Synthesis at a High Rate over the Ru Catalyst
ACS Catalysis, May 2020, 10, 10, p5614–5622

Prof Jonathan Burton and Pfizer
Organophotochemical SNAr Reactions of Mildly Electron‐Poor Fluoroarenes
European Journal of Organic Chemistry, May 2020, 18, p2766-2770

Profs Fernanda Duarte and Ed Anderson, and Janssen
Rationalizing the diverse reactivity of [1.1.1]propellane through σ–π-delocalization
Chemical Science, April 2020, 11, p4895-4903

Prof Darren Dixon and Bayer
Catalytic Enantioselective Direct Aldol Addition of Aryl Ketones to alpha-Fluorinated Ketones
Angewandte Chemie, Mar 2020, 59, 13, p5359-5364

Prof Ed Anderson and UCB
A Modular, Enantioselective Synthesis of Resolvins D3, E1, and Hybrids
Organic Letters, Feb 2020, 22, 4, p1510-1515

Prof Angela Russell and Summit Therapeutics, SHB Enterprises and Evotec
Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid
Angewandte Chemie, Feb 2020, 59, 6, p2420-2428

Profs Veronique Gouverneur and Michael Willis, and Janssen
Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes
J. Am. Chem. Soc. Jan 2020, 142, 2, p720–725

Prof Angela Russell and Summit Therapeutics
Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model
Tetrahedron, Jan 2020, 76, 2, 130819

Prof Angela Russell and Summit Therapeutics
Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase
Bioorganic Chemistry, Jan 2020, 94, 103395

Prof Michael Willis and Pfizer
Cyclic Alkenylsulfonyl Fluorides: Palladium-Catalyzed Synthesis and Functionalization of Compact Multifunctional Reagents
Angewandte Chemie, Dec 2019, 58, 52, 18859-18863

Prof Tim Claridge and Bruker
Triplet NOAH supersequences optimised for small molecule structure characterisation
MRC, Nov 2019, 57, 11, 946-952

Prof Timothy Donohoe and Eli Lilly
Transition-Metal-Free Reductive Hydroxymethylation of Isoquinolines
Angewandte Chemie, Oct 2019, 58, 44, 15697-15701

Prof Veronique Gouverneur and Janssen
Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid
Angewandte Chemie, Jun 2019, 58, 26, p8829-8833

Prof Timothy Donohoe and GSK
Rhodium-catalysed vinyl 1,4-conjugate addition coupled with Sharpless asymmetric dihydroxylation in the synthesis of the CDE ring fragment of pectenotoxin-4
Chemical Science, May 2019, 10, 6336-6340

Prof Ed Anderson and Janssen
A General Copper-Catalyzed Synthesis of Ynamides from 1,2-Dichloroenamides
Organic Letters, Apr 2019, 21, 8, 2918-2922

Prof Ed Anderson and Pfizer
Synthesis of Enantioenriched α-Chiral Bicyclo[1.1.1]pentanes
Organic letters, Apr 2019, 21, 7, 2408–2411

Prof Darren Dixon and Bayer
One-Pot Catalytic Enantioselective Synthesis of 2-Pyrazolines
Angewandte Chemie, Feb 2019, 58, 8, 2469-2473

Prof Justin Benesch and Waters Corp
Probing the Dissociation of Protein Complexes by Means of Gas-Phase H/D Exchange Mass Spectrometry
Journal of the American Society for Mass Spectrometry, Nov 2018, 30, 45–57

Prof Veronique Gouverneur, Pfizer and UCB
Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride
Chemical Science, 2019, 10, 3237-3241

Prof Stephen Fletcher and Vertex
Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
Nature Communications, Jan 2019, 10, 21

Prof Tim Donohoe and Eli Lilly
The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation
Nature Chemistry, Dec 2018, 11, 242–247. DOI 10.1038/s41557-018-0178-5

Prof Darren Dixon and Bayer
One‐Pot Catalytic Enantioselective Synthesis of 2‐Pyrazolines
Angewandte Chemie, Dec 2018. DOI 10.1002/anie.201811471

Prof Akane Kawamura and Promega Corporation
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors
Angewandte Chemie, Nov 2018. 10.1002/anie.201810179

Prof Michael Willis and Pfizer
Heterocyclic Allylsulfones as Latent Heteroaryl Nucleophiles in Palladium-Catalyzed Cross-Coupling Reactions
Journal of the American Chemical Society, Nov 2018, 140 (46), pp 15916–15923

Profs Carol Robinson and Luet Wong, and OMass
An electron transfer path connects subunits of a mycobacterial respiratory supercomplex
Science, Nov 2018, 362, 6418. DOI 10.1126/science.aat8923

Prof Michael Willis and Evotec
Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes
Organic & Biomolecular Chemistry, Oct 2018, 16, 7797-7800

Prof Darren Dixon and Astex
Photocatalytic Three-Component Umpolung Synthesis of 1,3-Diamines
Organic Letters, Oct 2018, 20, 21, 6794–6798

Prof Tom Brown and AstraZeneca
Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue
Scientific Reports, Sep 2018, DOI 10.1038/s41598-018-31897-2

Prof Angela Russell and AstraZeneca
Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors
ACS Chemical Biology, Sep 2018, DOI 10.1021/acschembio.8b00665

Prof Michael Willis and GlaxoSmithKline
Copper-Catalyzed Synthesis of Activated Sulfonate Esters from Boronic Acids, DABSO, and Pentafluorophenol
Organic Letters, Aug 2018, 20 (17), pp 5493–5496

Prof Carol Robinson and OMass
PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling
Nature, Jul 2018, 559, 423–427

Prof Harry Anderson and IBM
Polyyne formation via skeletal rearrangement induced by atomic manipulation
Nature Chemistry, Jul 2018, 10, 853–858

Prof Stuart Conway and GlaxoSmithKline
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
Bioorganic & Medicinal Chemistry, Jul 2018, 26 (11), 2937-2957

Profs Hagan Bayley, Justin Benesch and Carol Robinson, and OMass
Lipid binding attenuates channel closure of the outer membrane protein OmpF
PNAS, Jun 2018, DOI 10.1073/pnas.1721152115

Prof Tim Claridge and Bruker
Molecular structure from a single NMR supersequence
Chemical Communications, May 2018, 54, 7139-7142

Profs Justin Benesch and Carol Robinson, and Waters Corporation
Identifying key membrane protein lipid interactions using mass spectrometry
Nature Protocols, Apr 2018, 13, 1106–1120

Prof Edward Anderson and Pfizer
Synthesis and applications of highly functionalized 1-halo-3-substituted bicyclo[1.1.1]pentanes
Chemical Science, May 2018, DOI 10.1039/C8SC01355A

Prof Veronique Gouverneur and Lilly
Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
Science, May 2018, 360, 638-642

Profs Andrew Weller and Michael Willis with AstraZeneca
Rh(DPEPhos)-Catalyzed Alkyne Hydroxylation Using -Carbonyl-Substituted Aldehydes: Mechanistic Insight Leads to Low Catalyst Loadings that Enables Selective Catalysis on Gram-Scale
J. Am. Chem. Soc, May 2018, DOI: 10.1021/jacs.8b04086

Prof Tom Brown and Metabion
Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures
Chemical Communications, Apr 2018, DOI 10.1039/C8CC00738A

Profs Chris Schofield, Shabaz Mohammed and Dr Emily Flashman, with Novartis and AbbVie
YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase
Extremophiles, Mar 2018, 22, p553–562. DOI 10.1007/s00792-018-1016-9

Prof Tom Brown and AstraZeneca
Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue
Chemical Science, Mar 2018, 9, 3494-3502. DOI 10.1039/C7SC05448C

Prof Chris Schofield and GSK
Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces
ChemMedChem, Mar 2018, 13, 1051-1057

Prof Darren Dixon and UCB
Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macro domain 2
Bioorganic & Medicinal Chemistry, Mar 2018, DOI: 10.1016/j.bmc.2018.03.020

Prof Justin Benesch and Waters Corporation
Mass spectrometry beyond the native state
Current Opinion in Chemical Biology, Feb 2018, 42, 130-137

Profs Darren Dixon, Chris Schofield, Martin Smith, Mike Willis and UCB
Direct sulfonylation of anilines mediated by visible light
Chemical Science, 2018, 9, 629-633

Prof Dermot O'Hare and SCG
Slurry-Phase Ethylene Polymerisation Using Pentafluorophenyl- and Pentafluorophenoxy- Modified Solid Polymethulaluminoxanes
Organometallics, Jan 2018, 37, 156-164

Prof Fraser Armstrong and SCG
A hydrogen fuel cell for rapid, enzyme-catalysed organic synthesis with continuous monitoring
Chemical Communications, Jan 2018, 54, 972-975

Profs Steve Fletcher and Rob Paton with Vertex
Formation of quaternary centres by copper catalysed asymmetric conjugate addition to beta-substituted cyclopentneones with the aid of a quantitative structure-selectivity relationship
Chemical Science, Feb 2018, 9, 2628-2632

Prof Michael Willis and GSK
Oxidative Beta-Sulfonylation of Cyclic Amines
Chemical Science, Jan 2018, 9, 2295-2300

Prof Dermot O'Hare and SCG
Zirconium arena triple-decker sandwich complexes: synthesis, electronic structure and bonding
Chem. Commun. 2017, 53, 12048-12051

Profs Darren Dixon, Rob Paton, Christopher Schofield, Martin Smith, Mike Willis and UCB
A C-H Cyanation of 6-Ring N-Containing Heteroaromatics
Chem. Eur. J. 2017, 23, 14733-14737

Prof Andrew Baldwin and ZoBio
Automatic Assignment of Methyl-NMR Spectra of Supramolecular Machines Using Graph Theory
J. Am. Chem. Soc. 2017, 139, 9523-9533

Prof Mike Willis and UCB
One-pot, Three-Component Sulfonimidamide Synthesis exploiting the Sulfinylamine Reagent N-Sulfinyltritylamine, TrNSO
Angew. Chem. Int. Ed. 2017, 56, 14937-14941

Prof Carol Robinson and OMass
Native Desorption Electrospray Ionisation Liberates Soluble and Membrane Protein Complexes from Surfaces
Angew. Chem. Int. Ed.  2017, 56, 14463-14468

Prof Veronique Gouverneur and UCB
Derisking the Cu-Mediated F-18-Fluorination of Heterocyclic Positron Emission Tomography
J. Am. Chem. Soc. 2017, 139 (24), 8267-8276

Prof Tim Claridge and Bruker
NOAH - NMR Supersequences for Small Molecule Analysis and Structure Elucidation
Angew. Chem. Int. Ed.  2017, 129, 11941-11945

Prof Edman Tsang and SINOPEC
Decarboxylation of Lactones over Zn/ZSM-5: Elucidations of the Structure of the Active Site and Molecular Interactions
Angew. Chem. Int. Ed. 2017, 129, 10851-10856

Prof Tom Brown and AstraZeneca
Towards Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET
J. Am. Chem. Soc. 2017, 139 (27), 9271-9280

Prof Philip Mountford and SCG
Reactions of Titanium Imides and Hydrazides with Boranes
Organometallics 2017, 36, 3329-3342

Prof Veronique Gouverneur and UCB
Bridging the gaps in 18F PET tracer development
Nat. Chem. 2017, 9 (1), 1-3

Profs Luet Wong and Jeremy Robertson and Syngenta
Hydroxylation of anilines by engineered cytochrome P450(BM3)
Org. Biomol. Chem. 2017, 15, 8780-8787

Prof Tim Donohoe and GSK
Hydrogen Borrowing Catalysis with Secondary Alcohols: A New Route for the Generation of beta-Branched Carbonyl Compounds
J. Am. Chem. Soc. 2017, 139 (7), 2577-2580

Prof Mike Willis and Pfizer
Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalysed cross-coupling reactions with aryl halides
Chem. Sci. 2017, 8, 4437-4442

Prof Philip Mountford and Arlanxeo
Monometallic and Bimetallic Titanium K1-Amidinate Complexes as Olefin Polymerisation Catalysts
Organometallics, 2017, 36 (11), 2167-2181

Prof Carol Robinson and Spiber Technologies
Efficient protein production inspired by how spiders make silk
Nat. Commun. 2017, 8, 15504

Profs Dermot O'Hare and Edman Tsang and SCG
Hydrodeoxygenation of water-insoluble bio-oil to alkanes using highly dispersed Pd-Mo catalyst
Nature Comm. 2017, 8, 1591

Prof Veronique Gouverneur and Eli Lilly
The dual role of thiourea in the thiotrifluoromethylation of alkenes
Chem. Sci. 2017, 8, 1195-1199

Prof Ed Anderson and Pfizer
Mechanistic Study of Arylsilane Oxidation through 19-F NMR Spectroscopy
J. Am. Chem. Soc. 2017, 139 (17), 6138-6145

Prof Roel Dullens, Prof Dirk Aarts and Unilever
The effect of colloidal aggregates on fat crystal networks
Food Funct. 2017, 8 (1), 352-359

Prof Tim Donohoe and AstraZeneca
Catalytic Enolate Arylation with 3-Bromoindoles Allows the Formation of beta-Carbolines
J. Org. Chem. 2017, 82 (8), 4435-4443

Prof Philip Mountford and SCG
New Titanium Borylimido Compounds: Synthesis, Structure and Bonding
Inorg. Chem. 2017, 56, 10794-10814

Prof Veronique Gouverneur and Advion Biosystems
Synthesis and Reactivity of F-18-Labeled alpha,alpha-Difluoro-alpha(aryloxy(acetic Acids
Org. Lett. 2017, 19 (3), 568-571

Prof Darren Dixon and UCB
Discovery of a PCAF Bromodomain Chemical Probe
Angew. Chem. Int. Ed. 2017, 56, 827

Prof Mike Willis and Pfizer
One-pot palladium-catalysed synthesis of sulfonyl fluorides from aryl bromides
Chem. Sci. 2017, 8, 1233-1237