Patrick Rabe

Patrick Rabe

Patrick Rabe

Wellcome Mid Career Development Award Investigator


Research Interests

My group works in the area of synthetic organic chemistry, biochemistry and spectroscopy with a strong focus on time-resolved serial crystallography. Currently, we are interested in the detailed understanding of O2 dependant reactions responsible for the generation of light, in particular those from Luciferases (responsible for one of the most visually extraordinary effect in nature – bioluminescence). We are interested in the identification of intermediates and dynamics tuning catalysis to allow this remarkable process. We are using these model enzymes to study new tools to rapidly generate O2 for different spectroscopic methods and time-resolved crystallography experiments. Our work is very interdisciplinary and in close collaboration with Diamond Light Source. It provides excellent opportunities for students and researchers to work in a collaborative environment combining organic chemistry, chemical biology, biochemistry and cutting-edge serial crystallography and spectroscopy method development.


I studied chemistry at the University of Braunschweig in Germany. In 2016, I finished my PhD at the Kekulé-Institute of Organic Chemistry and Biochemistry at the University of Bonn on “Mechanistic Studies on Bacterial Terpene Synthases” with Prof. Jeroen S. Dickschat, which was awarded with the 2017 Dechema doctoral award. My passion to understand the details of macromolecular catalysis motivated me to start my postdoctoral research in the group of Prof. Christopher Schofield at the University of Oxford (funded by the Deutsche Akademie für Naturforscher Leopoldina, Germany). I was able to acquire new skills in (time-resolved serial) crystallography and spectroscopy method development with collaborators at Diamond Light Source. Since 2021, I am teaching as part of the SBMCDT biopolymers course at the University of Oxford. In 2023, I was awarded with a Career Development Award by the Wellcome Trust being able to start my independent research group.


+44 (0)1865 275419

Office 40.091, 2nd floor, CRL

Website: Rabe Group

Twitter/X: @Rabegroup