Dioxygen binding is controlled by the protein environment in non-heme FeII and 2-oxoglutarate oxygenases: a study on histone demethylase PHF8 and an ethylene-forming enzyme

Chaturvedi SS, Thomas MG, Bathir Jaber Sathik Rifayee S, White W, Wildey J, Warner C, Schofield CJ, Hu J, Hausinger RP, Karabencheva-Christova TG, Christov CZ

Invited for the cover of this issue are Christo Z. Christov and co-workers at Michigan Technological University, University of Oxford, and Michigan State University. The image depicts the oxygen diffusion channel in class 7 histone demethylase (PHF8) and ethylene-forming enzyme (EFE) and changes in the enzymes’ conformations upon binding. Read the full text of the article at 10.1002/chem.202300138.

Keywords:

ferrous compounds

,

oxygenases

,

histone demethylases

,

ketoglutaric acids

,

oxygen

,

transcription factors