Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.
Keywords:
Pyrazoles
,Ubiquitin-Protein Ligases
,Protein Kinases
,Protein Kinase Inhibitors
,Light
,Proteolysis
