The synthesis and reactivity of hydroxy hydroxamates as models for a prodrug form of hydroxylamine are described. Gamma-hydroxy hydroxamates were found to enable hydroxylamine release via lactonisation. Hydroxamates were found to undergo esterase catalysed hydrolysis.
Keywords:
Catalysis
,Esterases
,Hydrolysis
,Hydroxylamines
,Hydroxylation
,Lactones
,Magnetic Resonance Spectroscopy
,Molecular Structure
,Prodrugs
,Structure-Activity Relationship
