A short stereoselective synthesis of the Fusarium toxin equisetin, a potent inhibitor of HIV-1 integrase enzyme is described, using as the key step a stereoselective intramolecular Diels-Alder reaction of a fully conjugated E,E,E-triene with a trisubstituted gamma,delta-unsaturated beta-ketothioester.
Keywords:
Fusarium
,Molecular Structure
,Pyrrolidinones
,Stereoisomerism
,Tetrahydronaphthalenes
