Isolation of an intermediate in clavulanic acid biosynthesis

Baldwin JE, Adlington RM, Bryans JS, Bringhen AO, Coates JB, Crouch NP, Lloyd MD, Schofield CJ, Elson SW, Baggaley KH, Cassells R, Nicholson N

The operation of a primary isotope effect was utilised to enable a hitherto unknown intermediate in clavulanic acid biosynthesis to be isolated and characterised.