Total synthesis of the polyenoyltetramic acid polycephalin C

Longbottom DA, Morrison AJ, Dixon DJ, Ley SV

The total synthesis of the polyenoyltetramic acid polycephalin C is described. Key steps of the synthesis include a double Swern oxidation, double Takai reaction and a double Stille reaction. In addition, the absolute stereochemistry of the ring junction has been determined by synthesis of both isomers and comparison of their CD spectra with natural polycephalin C. © 2003 Elsevier Ltd. All rights reserved.